CAC Antibody Collection Index Page

Antibody Group
Advanced glycation end products (AGEs)

Autophagy and apoptosis

Bacteria-related

Calcium-binding proteins

Cancer
CD44 for enriching cancer stem cells
Tumor markers
Tumor inhibitors

Chaperones

Cytoskeleton

DNA damage
  UV-induced DNA lesions
  8-Nitroguanosine for oxidative stress research
  Nucleotide excision repair factors

Epigenetics and chromatin
Histone H3 variants
Post-translationally-modified histone H3
Chromatin structure modifiers
Drosophila chromatin

Epitope tags

Exosomes

Extracellular matrix
Glycosaminoglycans (GAGs)
Proteoglycans
Matrix and basement membrane
Cell adhesion and hemidesmosome-related
Bone and cartilage-related
Wound repair-related

Hedgehog pathway

Hormones

Immunology
Fish CD4 and CD8α
Allergic disease-related
Adaptive and innate immunity
Macrophages
Inflammatory cytokines
Viral recognition pathways
Vpr for HIV research

Insulin-like growth factor-related

Mitochondria-related

Neurobiology
Neurodegenerative disease markers
Muscarinic acetylcholine receptors
Miscellaneous

Nuclear import and export

Oxidative stress

Plant-related
Plant hormones
Plant autophagy and apoptosis
Plant stress response
Plant stress response

Proteasomes

Puromycin-specific

Reproductive biology

Small molecules

Stem cells
Novel iPS/ES markers
Pluripotency-associated

Sumoylation pathway

TGF-beta pathway
TGF-beta LAP-d
TGF-beta signaling

Transcription factors

Transporters

Tyrosine phosphatases

Ubiquitin-Proteasome Related

CAC Antibody Collection

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Sumoylation pathway

SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis. Four SUMO isoforms have been identified, which are SUMO1, SUMO2/3 and SUMO4. The small ubiquitin-like modifier (SUMO) pathway is conserved in all eukaryotes and plays pivotal roles in the regulation of gene expression, cellular signaling and the maintenance of genomic integrity. The SUMO catalytic cycle includes maturation, activation, conjugation, ligation and de-modification. The dysregulation of the SUMO system is associated with a number of diseases, particularly cancer. SUMOylation is widely involved in carcinogenesis, DNA damage response, cancer cell proliferation, metastasis and apoptosis. SUMO can be used as a potential therapeutic target for cancer. [from: Han ZJ, Feng YH, Gu BH, Li YM and Chen H. (2018) The post-translational modification, SUMOylation, and cancer (Review). International Journal Of Oncology. 52:1081-1094.]

Product name (click for order info)	Cat No (click for datasheet)	Host	Species specificity
Anti Small Ubiquitin-Related Modifier 2 (SUMO2) and Small Ubiquitin-Related Modifier 3 (SUMO3) mAb (Clone 3H12)	CAC-CE-044	RT	HU MS RT MKY

Product name	Anti Small Ubiquitin-Related Modifier 2 (SUMO2) and Small Ubiquitin-Related Modifier 3 (SUMO3) mAb (Clone 3H12)
Cat No	CAC-CE-042A
Description	SUMO is a Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. References: 1) Saitoh et al. (2006). Exp Cell Res. 312:1418-1430. This antibody is used in ref.1.
Host	RT
Species specificity	HU MS RT MKY
Figure 1
Figure 1	Immunocytochemistry/Immunofluorescence analysis of SUMO2/3 antibody (3H12) on mouse primary culture neurons.
Figure 2
Figure 2	Immunoblot analysis of SUMO1 antibody (4D12) and SUMO3 antibody (3H12) on HeLa cell extracts.