Bone Resorption Assay Plate

Cosmo Bio

Catalog No.: CSR-BRA-24P

Background

Useful for the research of skeletal metabolism This product is an assay kit for the measurement of bone resorption activity using a fluoresceinated calcium phosphate-coated plate (patent pending). The coated calcium phosphate is first bound to fluoresceinamine-labeled chondroitin sulfate (FACS), which is released from the calcium phosphate layer into conditioned medium by osteoclastic resorption activity. Bone resorption activity is evaluated by simply measuring the fluorescence intensity of the conditioned medium. This assayprovides a rapid evaluation system unlike that of the traditional pit assay

Features

1) Bone resorption activity is evaluated simply by measuring the fluorescence intensity of the medium.
2) The fluorescence excitation and emission wavelengthsare identical to those for the commonly-used fluorescent dye, FITC
3) Microscopic observation of cell morphology is possible.
4) Pit area analysis is also possible after removing the cells.
Ready to use, sterile components.

Citations for Bone Resorption Assay Plate – 60 Found

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Harada, Kana; Itoh, Hiromichi; Kawazoe, Yumi; Miyazaki, Shuichi; Doi, Kazuya; Kubo, Takayasu; Akagawa, Yasumasa; Shiba, Toshikazu. Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts. Plos One. 8(11):e78612. 

Harada, Kana; Itoh, Hiromichi; Kawazoe, Yumi; Miyazaki, Shuichi; Doi, Kazuya; Kubo, Takayasu; Akagawa, Yasumasa; Shiba, Toshikazu. Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts. Plos One. 8(11):e78612. 

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Mishima, Kenichi; Kitoh, Hiroshi; Ohkawara, Bisei; Okuno, Tatsuya; Ito, Mikako; Masuda, Akio; Ishiguro, Naoki; Ohno, Kinji. Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis. Ebiomedicine. 2015;2(12):2046-61. 

Ishikawa, Shintaro; Tamaki, Misako; Ogawa, Yui; Kaneki, Kiyomi; Zhang, Meng; Sunagawa, Masataka; Hisamitsu, Tadashi. Inductive Effect of Palmatine on Apoptosis in RAW 264.7 Cells. Evidence-Based Complementary And Alternative Medicine : Ecam. 2016:7262054. 

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Jin, Su Hyun; Kim, Hyunsoo; Gu, Dong Ryun; Park, Keun Ha; Lee, Young Rae; Choi, Yongwon; Lee, Seoung Hoon. Actin-binding LIM protein 1 regulates receptor activator of NF-κB ligand-mediated osteoclast differentiation and motility. Bmb Reports. 2018;51(7):356-361. 

Nishida, Miwa; Saegusa, Jun; Tanaka, Shino; Morinobu, Akio. S100A12 facilitates osteoclast differentiation from human monocytes. Plos One. 13(9):e0204140. 

Ohnuma, Kenichiro; Kasagi, Shimpei; Uto, Kenichi; Noguchi, Yoriko; Nakamachi, Yuji; Saegusa, Jun; Kawano, Seiji. MicroRNA-124 inhibits TNF-α- and IL-6-induced osteoclastogenesis. Rheumatology International. 2019;39(4):689-695. 

Lee, Kyung-Ann; Kim, Kyoung-Woon; Kim, Bo-Mi; Won, Ji-Yeon; Min, Hong Ki; Lee, Dhong Won; Kim, Hae-Rim; Lee, Sang-Heon. Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis. Arthritis Research & Therapy. 2019;21(1):283. 

Park, Keun Ha; Gu, Dong Ryun; Kim, Min Seuk; Lee, Seoung Hoon. Inhibitory Effect of Rosae Multiflorae Fructus Extracts on the Receptor Activator of NF-κB Ligand-Induced Osteoclastogenesis through Modulation of P38- and Ca(2+)-Mediated Nuclear Factor of Activated T-Cells Cytoplasmic 1 Expression. Journal Of Bone Metabolism. 2020;27(1):53-63. 

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Lee, Eun-Jung; Kang, Min-Kyung; Kim, Yun-Ho; Kim, Dong Yeon; Oh, Hyeongjoo; Kim, Soo-Il; Oh, Su Yeon; Na, Woojin; Kang, Young-Hee. Coumarin Ameliorates Impaired Bone Turnover by Inhibiting the Formation of Advanced Glycation End Products in Diabetic Osteoblasts and Osteoclasts. Biomolecules. 2020;10(7) 

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Gal, Minju; Tuan, Ha Manh; Park, Ju-Hee; Park, Kang-Hyeon; Kim, Okhwa; Min, Byung-Sun; Lee, Jeong-Hyung. Irilin D suppresses RANKL-induced osteoclastogenesis and prevents inflammation-induced bone loss by disrupting the NF-κB and MAPK signaling pathways. European Journal Of Pharmacology. 2024;982:176956. 

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Zhu, Kecheng; Sheng, Chunxiang; Zhang, Linlin; Yang, Yuying; Chen, Xiaojing; Jiang, Tao; Song, Jiaxi; Zhang, Deng; Wang, Xiao; Zhao, Hongyan; Sun, Lihao; Zhou, Libin; Tao, Bei; Liu, Jianmin. The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction. Cell Communication And Signaling : Ccs. 2025;23(1):26. 

Wang, Haojue; Yuan, Tao; Wang, Jingpeng; Li, Dengju; Lee, Wayne Yuk-Wai; Li, Ziqing; Sun, Shui. Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis. Arthritis Research & Therapy. 2025;27(1):54.