Anti Bovine Milk Exosome pAb (Rabbit, Ammonium Sulfate Purified)

Cosmo Bio LTD

Catalog No: CAC-EXO-AB-01

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Application: WB 
Clonality: Polyclonal 
Host: Rabbit 
Purification: Ammonium Sulfate 
Reactivity: Bovine 

Exosomes are membrane vesicles with a diameter of about 50 nm to 150 nm. They are secreted by most cells and are observed in body fluids such as saliva, blood, urine, amniotic fluid and malignant ascites. By encapsulating miRNA, mRNA, protein, micro peptides exosomes may be responsible for transmitting information to target cells or tissues.(1) It is known that cancer metastasis can be suppressed by neutralizing exosome signaling with antibodies specific for exosome surface antigens such as CD9 and CD63.(2) Exosomes are also present in the milk of a wide range of animals such as humans, cows and rats.(3) Furthermore, recent studies have demonstrated the utility of exosomes derived from raw milk as a means of orally administering anticancer agents.(4)

References:
1) Hoshino A, et al. (2015) Tumour exosome integrins determine organoorganic metabolism. Nature. 527(7578):329-35.
2) Nao Nishida-Aoki, et al. (2017) Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis. Mol Ther. 25(1):181-191.
3) Hirohisa Izumi, et al. (2015) Bovine milk exosomes contain microRNA and mRNA and is taken up by human macrophages.
4) Ashish K. Agrawal et al. (2017) Milk-derived exosomes for oral delivery of paclitaxel. Nanomedicine. 13(5):1627-1636.