Breast Milk Exosome, Human

Cosmo Bio

Catalog No.: CSR-EXHM100L

Product Description

Extracellular vesicles (EVs; including classical-exosomes, non-classical-exosomes, microvesicles, large oncosomes, apoptotic bodies, apoptotic vesicles, autophagic extracellular vesicles, amphisomes and ARRMs) are membrane vesicles of 40-1000 nm that are released into the extracellular milieu and body fluids from most cell types, including red blood cells, platelets, lymphocytes, dendritic cells, endothelial cells and tumor cells. These vesicles are classified into 2 types according to their secretory mechanism. Thus, classical-exosomes are formed in multivesicular endosomes, whereas microvesicles originate by direct budding from the plasma membrane. Although classical-exosome components vary by their originating cell type, a certain set of molecules appears likely to be shared, regardless of their origin. These molecules include the tetraspanin proteins CD9, CD63 and CD81; these proteins are thought to be essential components of the biogenesis mechanism of classical-exosomes. Accordingly, researchers have used CD9, CD63 and CD81 to isolate and characterize the purity of classical-exosome preparations.

Recently, exosomes have been discovered in the milk of a variety of mammals, including human. It was shown that several exosome markers, such as CD63 and CD81, were also expressed in human breast milk. It has been reported that human breast milk contains many microRNAs, especially those involved in immunity. It was suggested that these exosomal microRNAs might be transferred from mother to infant through breast milk. It has been reported that immunocytes are regulated by exosomes present in human breast milk. It has also been reported that exosomes derived from pig breast milk exhibited a growth-stimulating effect directly upon infant intestinal epithelial cells. Because of these studies, the function and mechanisms of action of exosomes in breast milk have attracted considerable attention.

Citations for Breast Milk Exosome, Human – 8 Found

Umezu, Tomohiro; Takanashi, Masakatsu; Murakami, Yoshiki; Ohno, Shin-Ichiro; Kanekura, Kohsuke; Sudo, Katsuko; Nagamine, Kenichi; Takeuchi, Shin; Ochiya, Takahiro; Kuroda, Masahiko. Acerola exosome-like nanovesicles to systemically deliver nucleic acid medicine via oral administration. Molecular Therapy. Methods & Clinical Development. 2021;21( 33850951):199-208. 

Chen, Hao; Yamakawa, Tsubasa; Inaba, Masafumi; Nakano, Michihiko; Suehiro, Junya. Characterization of Extra-Cellular Vesicle Dielectrophoresis and Estimation of Its Electric Properties. Sensors (Basel, Switzerland). 2022;22(9) 

Hoshino, Ayuko; Costa-Silva, Bruno; Shen, Tang-Long; Rodrigues, Goncalo; Hashimoto, Ayako; Tesic Mark, Milica; Molina, Henrik; Kohsaka, Shinji; Di Giannatale, Angela; Ceder, Sophia; Singh, Swarnima; Williams, Caitlin; Soplop, Nadine; Uryu, Kunihiro; Pharmer, Lindsay; King, Tari; Bojmar, Linda; Davies, Alexander E; Ararso, Yonathan; Zhang, Tuo; Zhang, Haiying; Hernandez, Jonathan; Weiss, Joshua M; Dumont-Cole, Vanessa D; Kramer, Kimberly; Wexler, Leonard H; Narendran, Aru; Schwartz, Gary K; Healey, John H; Sandstrom, Per; Labori, Knut Jørgen; Kure, Elin H; Grandgenett, Paul M; Hollingsworth, Michael A; de Sousa, Maria; Kaur, Sukhwinder; Jain, Maneesh; Mallya, Kavita; Batra, Surinder K; Jarnagin, William R; Brady, Mary S; Fodstad, Oystein; Muller, Volkmar; Pantel, Klaus; Minn, Andy J; Bissell, Mina J; Garcia, Benjamin A; Kang, Yibin; Rajasekhar, Vinagolu K; Ghajar, Cyrus M; Matei, Irina; Peinado, Hector; Bromberg, Jacqueline; Lyden, David. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527(7578):329-35. 

Genovese, Elizabeth A; Fish, Larry; Chaer, Rabih A; Makaroun, Michel S; Baril, Donald T. Risk stratification for the development of respiratory adverse events following vascular surgery using the Society of Vascular Surgery's Vascular Quality Initiative. Journal Of Vascular Surgery. 2017;65(2):459-470. 

Admyre, Charlotte; Johansson, Sara M; Qazi, Khaleda Rahman; Filén, Jan-Jonas; Lahesmaa, Riitta; Norman, Mikael; Neve, Etienne P A; Scheynius, Annika; Gabrielsson, Susanne. Exosomes with immune modulatory features are present in human breast milk. Journal Of Immunology (Baltimore, Md. : 1950). 2007;179(3):1969-78. 

Hillenmeyer, Maureen E; Ericson, Elke; Davis, Ronald W; Nislow, Corey; Koller, Daphne; Giaever, Guri. Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action. Genome Biology. 11(3):R30. 

Zhu, Hao; Owen, Markus R. Damped propagation of cell polarization explains distinct PCP phenotypes of epithelial patterning. Scientific Reports. 3:2528. 

Schmidt, Filipp; Fleming, Roland W. Visual perception of complex shape-transforming processes. Cognitive Psychology. 2016;90:48-70.