Anti CD9 Antigen (MRP-1/Tspan-29) mAb (Clone 12A12)

Cosmo Bio

Catalog No.: CAC-SHI-EXO-M01-50

CD9 is a cell surface glycoprotein which belongs to the tetraspanin superfamily. CD9 is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. Importantly, it is found on the surface of exosomes.

Exosomes are cell-derived vesicles bounded by a lipid bilayer membrane and exhibiting a diameter of 50 to 150 nm. They are secreted from cultured cells and are observed in body fluids such as saliva, blood, urine, amniotic fluid, malignant ascites. Recent studies indicate that exosomes contain various proteins and RNAs, suggesting a role in information transfer between cells.

This monoclonal antibody can be used to immunoprecipitate exosomes from serum and culture supernatants.

References:
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Product Specifications

• Application: IP, ELISA, WB, FC, IEM
• Reactivity: Human
• Clonality: Monoclonal (Clone No.: 12A12)
• Host: Mouse

Citations for Anti CD9 Antigen (MRP-1/Tspan-29) mAb (Clone 12A12) – 4 Found

Jingushi, Kentaro; Uemura, Motohide; Nakano, Kosuke; Hayashi, Yujiro; Wang, Cong; Ishizuya, Yu; Yamamoto, Yoshiyuki; Hayashi, Takuji; Kinouchi, Toshiro; Matsuzaki, Kyosuke; Kato, Taigo; Kawashima, Atsunari; Ujike, Takeshi; Nagahara, Akira; Fujita, Kazutoshi; Ueda, Koji; Tsujikawa, Kazutake; Nonomura, Norio. Leukocyte‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC. Oncology Reports. 2019;41(2):1293-1303. 

Torii, Yuka; Suzuki, Takako; Fukuda, Yuto; Haruta, Kazunori; Yamaguchi, Makoto; Horiba, Kazuhiro; Kawada, Jun-Ichi; Ito, Yoshinori. MicroRNA expression profiling of urine exosomes in children with congenital cytomegalovirus infection. Scientific Reports. 2024;14(1):5475. 

Masaki, Kanako; Ahmed, Abo Bakr F; Ishida, Takenori; Mikami, Yuuki; Funabashi, Hisakage; Hirota, Ryuichi; Ikeda, Takeshi; Kuroda, Akio. Chromatographic purification of small extracellular vesicles using an affinity column for phospholipid membranes. Biotechnology Letters. 2023;45(11-12):1457-1466. 

Yamada, Norihiro; Tominaga, Kana; Tominaga, Naoomi; Kobayashi, Ayumi; Niino, Chihiro; Miyagi, Yuta; Yamagata, Hirotaka; Nakagawa, Shin. Glycosylation changes of vWF in circulating extracellular vesicles to predict depression. Scientific Reports. 2024;14(1):29066.