Anti CD9 Antigen (MRP-1/Tspan-29) mAb (Clone 12A12)

Cosmo Bio

Catalog No.: CAC-SHI-EXO-M01-50

Product Description

CD9 is a cell surface glycoprotein which belongs to the tetraspanin superfamily. CD9 is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. Importantly, it is found on the surface of exosomes.

Exosomes are cell-derived vesicles bounded by a lipid bilayer membrane and exhibiting a diameter of 50 to 150 nm. They are secreted from cultured cells and are observed in body fluids such as saliva, blood, urine, amniotic fluid, malignant ascites. Recent studies indicate that exosomes contain various proteins and RNAs, suggesting a role in information transfer between cells.

This monoclonal antibody can be used to immunoprecipitate exosomes from serum and culture supernatants.

References:

1) Shigeyasu Tsuda et al., Scientific Reports volume 7, Article number: 12989 (2017)
2) N Nishida-Aoki et al., Mol Ther. 2017 Jan 4;25(1):181-191. doi: 10.1016/j.ymthe.2016.10.009.
3) Matsuzaki K et al., Oncotarget. 2017 Apr 11; 8(15): 24668–24678. doi: 10.18632/oncotarget.14969
4) Kazutoshi Fujita et al., Sci Rep. 2017; 7: 42961. doi: 10.1038/srep42961
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8) Ueda K et al., Sci Rep. 2014 Aug 29;4:6232. doi: 10.1038/srep06232.

Product Specifications

• Application: IP, ELISA, WB, FC, IEM
• Reactivity: Human, Bovine
• Clonality: Monoclonal 25175028 (Clone No.: 12A12)
• Host: Mouse
• Immunogen: Human CD9 (a.a 113-195)

Citations for Anti CD9 Antigen (MRP-1/Tspan-29) mAb (Clone 12A12) – 12 Found

Jingushi, Kentaro; Uemura, Motohide; Nakano, Kosuke; Hayashi, Yujiro; Wang, Cong; Ishizuya, Yu; Yamamoto, Yoshiyuki; Hayashi, Takuji; Kinouchi, Toshiro; Matsuzaki, Kyosuke; Kato, Taigo; Kawashima, Atsunari; Ujike, Takeshi; Nagahara, Akira; Fujita, Kazutoshi; Ueda, Koji; Tsujikawa, Kazutake; Nonomura, Norio. Leukocyte‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC. Oncology Reports. 2019;41(2):1293-1303. 

Torii, Yuka; Suzuki, Takako; Fukuda, Yuto; Haruta, Kazunori; Yamaguchi, Makoto; Horiba, Kazuhiro; Kawada, Jun-Ichi; Ito, Yoshinori. MicroRNA expression profiling of urine exosomes in children with congenital cytomegalovirus infection. Scientific Reports. 2024;14(1):5475. 

Masaki, Kanako; Ahmed, Abo Bakr F; Ishida, Takenori; Mikami, Yuuki; Funabashi, Hisakage; Hirota, Ryuichi; Ikeda, Takeshi; Kuroda, Akio. Chromatographic purification of small extracellular vesicles using an affinity column for phospholipid membranes. Biotechnology Letters. 2023;45(11-12):1457-1466. 

Yamada, Norihiro; Tominaga, Kana; Tominaga, Naoomi; Kobayashi, Ayumi; Niino, Chihiro; Miyagi, Yuta; Yamagata, Hirotaka; Nakagawa, Shin. Glycosylation changes of vWF in circulating extracellular vesicles to predict depression. Scientific Reports. 2024;14(1):29066. 

Zhao, Yunsheng; Ma, Xiaofang; Fan, Lingling; Mao, Fuying; Tian, Hongling; Xu, Rui; Cao, Zhe; Zhang, Xinhui; Fu, Xueyan; Sui, Hong. Discrimination of geographical origin of cultivated Polygala tenuifolia based on multi-element fingerprinting by inductively coupled plasma mass spectrometry. Scientific Reports. 2017;7(1):12577. 

Genovese, Elizabeth A; Fish, Larry; Chaer, Rabih A; Makaroun, Michel S; Baril, Donald T. Risk stratification for the development of respiratory adverse events following vascular surgery using the Society of Vascular Surgery's Vascular Quality Initiative. Journal Of Vascular Surgery. 2017;65(2):459-470. 

Li, Haohuan; Zhang, Xiaolong; Cao, Yiping; Hu, Song; Peng, Fei; Zhou, Jianlin; Li, Jianping. Association between EN1 rs4144782 and susceptibility of knee osteoarthritis: A case-control study. Oncotarget. 2017;8(22):36650-36657. 

Laughon, Barbara E; Nacy, Carol A. Tuberculosis - drugs in the 2016 development pipeline. Nature Reviews. Disease Primers. 2017;3:17015. 

Taylor, Gary S; Kent, Deborah S. Potential economic pests of solanaceous crops: a new species of Solanum-feeding psyllid from Australia and first record from New Zealand of Acizzia solanicola (Hemiptera: Psyllidae). Zootaxa. 2013;3613:257-73. 

Yeatman, Jason D; Richie-Halford, Adam; Smith, Josh K; Keshavan, Anisha; Rokem, Ariel. A browser-based tool for visualization and analysis of diffusion MRI data. Nature Communications. 2018;9(1):940. 

Decimi, Valentina; Fazio, Grazia; Dell'Acqua, Fabiola; Maitz, Silvia; Galbiati, Marta; Rizzari, Carmelo; Biondi, Andrea; Cazzaniga, Giovanni; Selicorni, Angelo. Williams syndrome and mature B-Leukemia: A random association?. European Journal Of Medical Genetics. 2016;59(12):634-640. 

Liu, Xuhang; Zheng, Qi; Vrettos, Nicholas; Maragkakis, Manolis; Alexiou, Panagiotis; Gregory, Brian D; Mourelatos, Zissimos. A MicroRNA precursor surveillance system in quality control of MicroRNA synthesis. Molecular Cell. 2014;55(6):868-879.