Anti-AKAP4 mAb (clone 7E10)

4BioDx

Catalog No.: BDX-4BDX-1602S

Product Description

Mouse monoclonal antibody clone 7E10 recognizes the carboxy-terminal region of A-kinase anchor protein 4 (AKAP4) and is suitable for Western Blot, for Immunohistochemistry, for ELISA, for Electron Microscopy and Immunofluorescence.

AKAP4 (A-Kinase Anchor Protein 4) protein belongs to the family of A-kinase anchor proteins (AKAPs) all sharing a common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the PKA holoenzyme to discrete locations within the cell.

The human AKAP4 gene is located on chromosome X and encodes a 854 amino acid polypeptide localized in the fibrous sheath of the sperm flagellum, AKAP4 plays a major role in sperm motility. AKAP4 is also named AKAP-4, AKAP82 (A-Kinase Anchor Protein 82 KDa), PRKA4 (Protein Kinase A Anchoring Protein 4), HI, CT99 (Cancer/Testis Antigen 99), FSC1 (Fibrous sheath component 1) or P82.

Mouse monoclonal antibody clone 7E10 (reference 4BDX-1602) recognizes the carboxy-terminal region of A-kinase anchor protein 4 (AKAP4) and is suitable for Western Blot, for Immunohistochemistry and Immunofluorescence.

Check out the 4BioDx antibody with the reference 4BDX-1701 (clone 6F12) that recognizes the N-terminal region of A-kinase anchor protein 4 (AKAP4) and is suitable for Western Blot, Immunohistochemistry, ELISA, Electron Microscopy and Immunofluorescence.

Product Specifications

• Application: IEM, ELISA, IF
• Reactivity: Sheep, Bovine, Equine, Porcine, Human
• Clonality: Monoclonal (Clone No.: 7E10)
• Host: Mouse

Citations for Anti-AKAP4 mAb (clone 7E10) – 9 Found

Dordas-Perpinyà, Marta; Sergeant, Nicolas; Ruelle, Isabelle; Bruyas, Jean-François; Charreaux, Frédéric; Michaud, Sandrine; Carracedo, Sara; Catalán, Jaime; Miró, Jordi; Delehedde, Maryse; Briand-Amirat, Lamia. ProAKAP4 Semen Concentrations as a Valuable Marker Protein of Post-Thawed Semen Quality and Bull Fertility: A Retrospective Study. Veterinary Sciences. 2022;9(5) 

Benderradji, Hamza; Barbotin, Anne-Laure; Leroy-Billiard, Maryse; Prasivoravong, Julie; Marcelli, François; Decanter, Christine; Robin, Geoffroy; Mitchell, Valérie; Rigot, Jean-Marc; Bongiovanni, Antonino; Sauve, Florent; Buée, Luc; Maurage, Claude-Alain; Cartigny, Maryse; Villers, Arnauld; Prevot, Vincent; Catteau-Jonard, Sophie; Sergeant, Nicolas; Giacobini, Paolo; Pigny, Pascal; Leroy, Clara. Defining Reference Ranges for Serum Anti-Müllerian Hormone on a Large Cohort of Normozoospermic Adult Men Highlights New Potential Physiological Functions of AMH on FSH Secretion and Sperm Motility. The Journal Of Clinical Endocrinology And Metabolism. 2022;107(7):1878-1887. 

Malo, Clara; Carracedo, Sara; Delehedde, Maryse; Sergeant, Nicolas; Skidmore, Julian Alexandra. Identification of proAKAP4 concentration variations in dromedary sperm and their correlation with monthly semen parameters. Reproduction & Fertility. 2021;2(4):268-279. 

Blommaert, D; Sergeant, N; Delehedde, M; Donnay, I; Lejeune, J P; Franck, T; Serteyn, D. First results about ProAKAP4 concentration in stallion semen after cryopreservation in two different freezing media. Cryobiology. 2021;102( 34302806):133-135. 

Scovell, Jason M; Bournat, Juan C; Szafran, Adam T; Solis, Minerva; Moore, Joshua; Rivera, Armando; Chen, Ching H; Zhang, Jason; Wilken, Nathan; Seth, Abhishek; Jorgez, Carolina J. PRSS50 is a testis protease responsible for proper sperm tail formation and function. Development (Cambridge, England). 2021;148(8) 

Griffin, Róisín A; Swegen, Aleona; Baker, Mark; Aitken, Robert John; Skerrett-Byrne, David A; Silva Rodriguez, Antonio; Martín-Cano, Francisco E; Nixon, Brett; Peña, Fernando J; Delehedde, Maryse; Sergeant, Nicolas; Gibb, Zamira. Mass spectrometry reveals distinct proteomic profiles in high- and low-quality stallion spermatozoa. Reproduction (Cambridge, England). 2020;160(5):695-707. 

Langlade, Camille; Buff, Samuel; Dias, Catia; Commin, Loris. Assessment of Optimized Frozen/Thawed Semen Samples in Canines with the New A-Kinase Anchor Protein 4 Precursor Biomarker. Biopreservation And Biobanking. 2020;18(5):409-414. 

Blommaert, D; Sergeant, N; Delehedde, M; Jouy, N; Mitchell, V; Franck, T; Donnay, I; Lejeune, J P; Serteyn, D. Expression, localization, and concentration of A-kinase anchor protein 4 (AKAP4) and its precursor (proAKAP4) in equine semen: Promising marker correlated to the total and progressive motility in thawed spermatozoa. Theriogenology. 2019;131( 30947075):52-60. 

Nixon, Brett; Bernstein, Ilana R; Cafe, Shenae L; Delehedde, Maryse; Sergeant, Nicolas; Anderson, Amanda L; Trigg, Natalie A; Eamens, Andrew L; Lord, Tessa; Dun, Matthew D; De Iuliis, Geoffry N; Bromfield, Elizabeth G. A Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells. Frontiers In Cell And Developmental Biology. 7( 31921838):319.