Anti-AKAP4 mAb (clone 7E10)

4BioDx

Catalog No: BDX-4BDX-1602S

Application: IEM, ELISA, IF 
Clonality: Monoclonal 
Host: Mouse 
Reactivity: Sheep, Bovine, Equine, Porcine, Human 

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Mouse monoclonal antibody clone 7E10 recognizes the carboxy-terminal region of A-kinase anchor protein 4 (AKAP4) and is suitable for Western Blot, for Immunohistochemistry, for ELISA, for Electron Microscopy and Immunofluorescence.

AKAP4 (A-Kinase Anchor Protein 4) protein belongs to the family of A-kinase anchor proteins (AKAPs) all sharing a common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the PKA holoenzyme to discrete locations within the cell.

The human AKAP4 gene is located on chromosome X and encodes a 854 amino acid polypeptide localized in the fibrous sheath of the sperm flagellum, AKAP4 plays a major role in sperm motility. AKAP4 is also named AKAP-4, AKAP82 (A-Kinase Anchor Protein 82 KDa), PRKA4 (Protein Kinase A Anchoring Protein 4), HI, CT99 (Cancer/Testis Antigen 99), FSC1 (Fibrous sheath component 1) or P82.

Mouse monoclonal antibody clone 7E10 (reference 4BDX-1602) recognizes the carboxy-terminal region of A-kinase anchor protein 4 (AKAP4) and is suitable for Western Blot, for Immunohistochemistry and Immunofluorescence.

Check out the 4BioDx antibody with the reference 4BDX-1701 (clone 6F12) that recognizes the N-terminal region of A-kinase anchor protein 4 (AKAP4) and is suitable for Western Blot, Immunohistochemistry, ELISA, Electron Microscopy and Immunofluorescence.

Citations for Anti-AKAP4 mAb (clone 7E10) – 24 Found

Dordas-Perpinya et al. 2022. ProAKAP4 Semen Concentrations as a Valuable Marker Protein of Post-Thawed Semen Quality and Bull Fertility: A Retrospective Study. Veterinary Sciences. 9(5):224.   , Journal

Dordas-Perpinya et al. 2022. ProAKAP4 concentrations in stallion and donkey: Comparison with kinetic parameters, motility and concentration. . Reproduction in Domestic Animals. 57(1):61.  Journal

Benderradji et al. 2022. Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men. J Clin Endocrinol Metab. 107(7):1878-1887.   , Journal

Malo et al. 2021. Identification of proAKAP4 concentration variations in dromedary sperm and their correlation with monthly semen parameters. Reproduction and Fertility. 2(4):268-79.   , Journal

Blommaert et al. 2021. First results about ProAKAP4 concentration in stallion semen after cryopreservation in two different freezing media. Cryobiology. 102:133-35.   , Journal

Scovell et al. 2021. PRSS50 is a testis protease responsible for proper sperm tail formation and function. . Development . 148(8):197558.   , Journal

Griffin et al. 2020. Mass spectrometry reveals distinct proteomic profiles in high- and low-quality stallion spermatozoa. . Reproduction. 160(5):695-707.   , Journal

Delehedde et al. 2020. Cigarette smoking affects the sperm-specific proAKAP4 concentrations and impairs both spermatogenesis and sperm quality. Andrology. 8(Supp 1):45-46.  Journal

Langlade et al. 2020. Assessment of Optimized Frozen/Thawed Semen Samples in Canines with the New A-Kinase Anchor Protein 4 Precursor Biomarker. Biopreserv Biobank. 18(5):409-414.   , Journal

Sergeant et al. 2020. Proteolysis of proAKAP4 in semen as a regulatory sensor of sperm quality and functionality. . Andrology. 8(Supp 1):44-45.  Journal

Carracedo et al. 2020. The sperm specific proAKAP4 polypeptide exhibited conserved functions, localizations and metabolism among mammals.. Animal Reproduction Science. 220:106448.  Journal

Sergeant et al. 2020. Assessment of the proAKAP4 concentrations as a pertinent sperm parameter to select extenders and preservatives of stallion semen. Animal Reproduction Science. 220:106449.  Journal

Ruelle et al. 2020. ProAKAP4 concentrations in semen as a predictive tool of bull fertility: A preliminary study. . Reproduction, Fertility and Development. 32(1):199.  Journal

Blommaert et al. 2019. Expression, localization, and concentration of A-kinase anchor protein 4 (AKAP4) and its precursor (proAKAP4) in equine semen: promising marker correlated to the total and progressive motility in thawed spermatozoa.. Theriogenology. 131:52-60.   , Journal

Nixon et al. 2019. A Kinase Anchor Protein 4 is vulnerable to oxidative adduction in male germ cells. . Frontiers in Cell and Developmental Biology . 7:319.   , Journal

Delehedde et al. 2019. ProAKAP4 polypeptide as a biomarker of sperm functionality and male fertility disorders. . Int J Gynecol and Reprod Sci. . 2(1):13-19.  Journal

Delehedde et al. 2019. ProAKAP4 concentrations as an indicator of good spermatogenesis and sperm quality under oxidative stress conditions. . Andrology. 7(1):86.  Journal

Ruelle et al. 2019. Assessment of the sperm specific protein proAKAP4 as a marker to evaluate sperm quality and fertility in Holstein bulls.. Rev. Bras. Reprod. Anim. 43(2):472.  Journal

Le Couazer et al. 2019. ProAKAP4 as a valuable marker to assess sperm quality in dogs.. Reproduction in Domestic Animals. 54(2):91-92.  

Le Couazer et al. 2019. Expression of proAKAP4 in dog semen as promising marker of sperm quality. . Reproduction in Domestic Animal. . 54(S3):73.  Journal

Sergeant et al. 2019. The sperm specific protein proAKAP4 as an innovative marker to evaluate sperm quality and fertility. Journal of Dairy & Veterinary Sciences. 11:43466.  Journal

Delehedde et al. 2018. Concentration of proAKAP4 as a pertinent read-out of sperm quality in mammals. . Animal Reproduction Science. . 194:24.  Journal

Blommaert et al. 2018. Significant correlation between the proAKAP4 concentration and the total and progressive motility in stallion sperm after thawing. . Journal of Equine Veterinary Science. 66:43.  Journal

Sergeant et al. 2016. Investigating proteomic methods and tools to assess sperm quality. Animal Reproduction Science . 169: 99–135.  Journal