T-Select H-2Db Influenza NP Tetramer-ASNENMDTM-APC

MBL Life Sciences

Catalog No.: MBL-TS-M502-2

Product Description

Anti-mouse CD8 clone choice is critical when mouse MHC I tetramers, as some clones, including 53-6.7, lead to high background staining of all CD8+ T cells, rather than the antigen-specific ones. For best results, clone KT15 in FITC (MBL-K0227-4) is recommended. Additional information can be found in the datasheet that accompanies mouse class I tetramers, as well as the following reference containing a protocol for performing a cross titration series for optimization: Current Protocols in Immunology, MHC-Peptide tetramers to Visualize Antigen-Specific T Cells, Section 17.3.23-24, Supplement 220

Product Specifications

• Application: FC
• Reactivity: Mouse
• Conjugation: APC
• Immunogen: Influenza nucleoprotein (NP)
• Peptide Sequence: ASNENMDTM
• Class: Class I
• Sequence Location: 366-374
• MHC Allele: H-2D^b

Citations for T-Select H-2Db Influenza NP Tetramer-ASNENMDTM-APC – 2 Found

Koyama, Shohei; Ishii, Ken J; Kumar, Himanshu; Tanimoto, Takeshi; Coban, Cevayir; Uematsu, Satoshi; Kawai, Taro; Akira, Shizuo. Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. Journal Of Immunology (Baltimore, Md. : 1950). 2007;179(7):4711-20. 

Nakamura, Risa; Maeda, Naoyoshi; Shibata, Kensuke; Yamada, Hisakata; Kase, Tetsuo; Yoshikai, Yasunobu. Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury. Journal Of Virology. 2010;84(11):5574-82.