Recombinant Human Fibroblast Growth Factor Basic (FGF-2)

ORF Biologics

Catalog No.: ORF.GF.FGF2-10

Product Description

Fibroblast Growth Factor 2 (FGF-2), also known as basic FGF, is a potent mitogenic and angiogenic cytokine that plays a crucial role in cell proliferation, survival, and differentiation across various tissue types. It exerts its biological effects by binding to FGF receptors (FGFRs) in the presence of heparan sulfate proteoglycans, activating downstream signaling pathways such as MAPK, PI3K/AKT, and PLCγ. These pathways regulate diverse cellular processes including stem cell self-renewal, neurogenesis, and vascular development. FGF-2 is expressed in a wide range of tissues and is essential during embryogenesis for mesoderm induction, neural patterning, and organogenesis. In adult tissues, it supports wound healing, angiogenesis, and tissue regeneration. Due to its broad bioactivity, recombinant FGF-2 is widely used in vitro to maintain pluripotent stem cells, promote proliferation of mesenchymal and neural progenitors, and support endothelial cell expansion. It is also a critical component in tissue engineering, cancer biology, and regenerative medicine research.

Product Application

• Maintenance and expansion of iPSCs in defined, feeder-free culture systems
• Pluripotent and multipotent stem cell proliferation, including hESCs and MSCs
• Neural stem cell growth and differentiation in developmental and disease models
• Angiogenesis and vascular biology research, including endothelial cell expansion
• Wound healing and tissue regeneration studies
• Cancer biology investigations, particularly in tumor growth and angiogenesis
• Mesodermal and ectodermal lineage specification in differentiation protocols
• Tissue engineering and biomaterial development for regenerative applications

Format: Lyophilized

Product Specifications