Recombinant Human Brain-Derived Neurotrophic Factor (BDNF)

ORF Biologics

Catalog No.: ORF.GF.BDNF-10

Product Description

Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family, essential for the development, survival, and plasticity of neurons in the central and peripheral nervous systems. It binds primarily to the TrkB receptor, triggering intracellular signaling cascades such as MAPK, PI3K, and PLCγ pathways, which regulate neuronal differentiation, synaptic growth, and long-term potentiation—key mechanisms underlying learning and memory. BDNF is initially produced as a precursor protein (proBDNF), which is proteolytically cleaved to generate mature BDNF. Both forms have distinct biological functions: mature BDNF promotes survival and synaptic strengthening, while proBDNF can induce apoptosis or synaptic pruning through p75NTR signaling. BDNF expression is tightly regulated by neuronal activity and is influenced by environmental stimuli such as exercise and stress. Recombinant BDNF is commonly used in vitro and in vivo to study neural development, neurodegenerative diseases, psychiatric disorders, and to support the survival and growth of neurons in culture.

Product Application

• Neuronal differentiation and outgrowth assays
• Neural stem cell maintenance
• Neuroprotection in in vitro or in vivo models
• Screening of neuroactive compounds
• Research in neuroscience applications such as depression, Alzheimer’s disease, and TBI

Format: Lyophilized

Product Specifications