LRRC15 is expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression is induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. １） This product is a two-step sandwich ELISA kit to detect LRRC15 protein using a couple of highly specific monoclonal antibodies against the extracellular domain of human LRRC15.
Features
・Detects high sensitivity Human LRRC15 by a two-step sandwich method using solid phase anti LRRC15 antibody and HRP conjugated anti LRRC15 antibody.
・The detection limit and quantification limit are 3.0pg/mL and 9.1pg/mL .
・No special equipment is required. Standard microplate reader capable of reading at 450nm will do the job.
