High Sensitivity 6-4PP/(6-4)Photoproducts ELISA kit (TMB) Ver.2

Cosmo Bio

Catalog No.: CSR-NM-MA-K004V2

Product Description

This High Sensitivity (6-4) photoproducts (6-4PPs) ELISA Kit is the only commercially available ELISA utilizing anti-6-4PPs clone 64M-2 and has been optimized for high sensitivity detection of 6-4PPs in DNA purified from cultured cells or from skin epidermis. This ELISA detects 6-4PPs from dipyrimidines in all DNA sequence contexts (i.e., TT, TC, CT and CC). Thus, the availability and convenience of this ELISA Kit will contribute to further understanding molecular mechanisms involved in cellular responses to UV radiation and DNA damage with applications across many research fields including cancer research, photobiology, dermatology, ophthalmology, immunology, and cosmetics science.

Citations for High Sensitivity 6-4PP/(6-4)Photoproducts ELISA kit (TMB) Ver.2 – 5 Found

Zhou, Shuyan; Zhang, Yi; Li, Zongzhu; Li, Zhuqing; Latham, Patricia S; Meng, Yunxiao; Chen, Wen; Yang, Penghua; Hou, Chunyan; Ma, Junfeng; Zhu, Wenge. And-1 coordinates with polymerase δ to regulate nucleotide excision repair and UVB-induced skin tumorigenesis. Nature Communications. 2025;16(1):9313. 

Gautam, Amit; Fawcett, Heather; Burdova, Kamila; Brazina, Jan; Caldecott, Keith W. APE1-dependent base excision repair of DNA photodimers in human cells. Molecular Cell. 2023;83(20):3669-3678.e7. 

Yu, Lei; Xu, Si-Yuan; Luo, Xin-Cheng; Ying, Sheng-Hua; Feng, Ming-Guang. Rad1 and Rad10 Tied to Photolyase Regulators Protect Insecticidal Fungal Cells from Solar UV Damage by Photoreactivation. Journal Of Fungi (Basel, Switzerland). 2022;8(11) 

Steurer, Barbara; Turkyilmaz, Yasemin; van Toorn, Marvin; van Leeuwen, Wessel; Escudero-Ferruz, Paula; Marteijn, Jurgen A. Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair. Nucleic Acids Research. 2019;47(7):3536-3549. 

Wang, Ding-Yi; Fu, Bo; Tong, Sen-Miao; Ying, Sheng-Hua; Feng, Ming-Guang. Two Photolyases Repair Distinct DNA Lesions and Reactivate UVB-Inactivated Conidia of an Insect Mycopathogen under Visible Light. Applied And Environmental Microbiology. 2019;85(4)