GIST-T1 Cell Line

Cosmo Bio

Catalog No.: PMC-GIST01C

Product Description

Human Cell Line GIST-T1 Cells, cryopreserved : 1.0x10⁶ cells / 1vial 
Not included: GIST-T1 Cell Culture Media (PMC-GISTM) or GIST-T1 Cell Culture Media (without antibiotics) (PMC-GISTMA)
Please use either of the recommended media (PMC-GISTM/PMC-GISTMA) for the culture of GIST-T1.
Using media other than what’s recommended will NOT be under the warranty.

Precautions:

・Because of cells derived from human tissue, please always wear gloves and safety glasses when working them.
・Remove the cryovial from the dry ice packaging and immediately place into liquid nitrogen storage until use.
・Based on the license agreement of Techno network Shikoku and Kochi University, GIST-T1 cell is prohibited to provide (distribution, lending, transfer, licnsing, ets.) to a third party.

Cosmo Bio CANNOT guarantee the cells cryopreserved in customer's laboratory.

Background

Gastrointestinal stromal tumors (GISTs) are one of the submucosal tumor, occur in the stomach, the small intestine and the esophagus, unlike most gastrointestinal tumors. GISTs are considered to arise from the interstitial cells of Cajal, the pacemaker cells of the gut. The GIST-T1 is a cell line derived from GISTs of the stomach in a Japanese woman and established by Takahiro Taguchi; associate professor, Graduate School of Integrated Arts and Sciences, Kochi-University, Kochi, Japan. 

Gastrointestinal stromal tumors (GISTs) are one of the submucosal tumors which occur in the stomach, the small intestine and the esophagus, unlike most gastrointestinal tumors. GISTs are considered to arise from the interstitial cells of Cajal and the pacemaker cells of the gut. 

GIST-T1 is a cell line derived from GISTs of the stomach of a Japanese woman and was established by Takahiro Taguchi; associate professor, Graduate School of Integrated Arts and Sciences, Kochi-University, Kochi, Japan. 

Specifications

Culture Medium components: DMEM, FBS, antibiotic, etc. 

General Information

Organism	Homo sapiens, human
Tissue	Stomach
Cultural	Properties Adherent
Biosafety	Level 1
Gender	Female
Ethnicity	Asian
Virus Check	HIV-1(-), HTLV-1(-), HBV(-), HCV(-), T.pallidum(-)
Quality Check	Mycoplasma (-)

Precautions

• Because cells are derived from human tissue, please always wear gloves and safety glasses when working with them.
• Remove the cryovial from the dry ice packaging and immediately place into liquid nitrogen storage until use.
• Based on the license agreement of Techno network Shikoku and Kochi University, GIST-T1 cell is prohibited to provide (distribution, lending, transfer, licnsing, ets.) to a third party.

Agreement for purchasing “GIST-T1 cells” Please agree to  the following:   (1)  We will use the GIST-T1 culture kit for research use only.   (2) We will ensure within the terms that the line is only to be used by the 3rd party for the project it is intended to support and that upon completion the material will be returned or destroyed.   (3)  We shall not distribute, lending, transfer, licensing, assign or let use GIST-T1 cells to a third party beyond the scope of our control or responsibility. Please download and print the agreement form (PDF file) Please fax or e-mail the filled out form to Cosmo Bio Co., Ltd. prior to placing your order with us.

Experimental example

 NOTE:Please use the recommended media (Cat.no# PMC-GISTM-COS) for the culture of GIST-T1.
Using media other than what’s recommended will NOT be under the warranty.
NOTE:Cosmo Bio CANNOT guarantee the cells cryopreserved in customer's laboratory.

Protocol

 A) Thawing of Cells

1) Prepare a 100mm dish (Note: 100mm dish is recommended).
2) Warm culture medium to 37°C.
3) Prepare a conical tube (for 15mL) added 10mL of culture medium.
4) Carefully remove the cryovial from liquid nitrogen and thaw cells in a water bath at 37°C for 90 seconds.
5) Transfer the cryovial into a laminar flow hood. Before opening, wipe the outside of the vial with 70% ethanol.
6) Gently transfer the thawed cell suspension (1mL) into 10 mL of culture medium.
7) Transfer 1mL of culture medium in the same conical tube back to the cryovial and pour the contents back to 15mL conical tube.
8) Centrifuge the cell suspension at approximately 200 ×g for 5 minutes at 4°C.
9) Aspirate the supernatant without disrupting the pellet and resuspend the cells in 10mL of culture medium.
10) Transfer the cell suspension to 100mm dish and incubate the cells in 37°C, 5% CO2 incubator.
11) Replace the medium with fresh pre-warmed culture medium every 2 to 3 days.

B) Subculturing Note: Allow culture medium, HBSS(or PBS(-)), and 0.25% Trypsin to come to room temperature before use.

1) When the cells reach 70 -90% of confluent, they should be subcultured.
2) Aspirate the medium. Rinse the dish with 10mL of HBSS or PBS (-).
3) Add 1mL of 0.25% Trypsin, then incubate at 37°C for 4-6 minutes.
4) Add 10mL of culture medium and disperse the cells with gentle pipetting.
5) Transfer the cell suspension to conical tube and centrifuge at 200 ×g for 5 minutes at 4°C.
6) Aspirate the supernatant without disrupting the pellet and resuspend the cells in 10mL of culture medium.
7) Dilute the cell suspension by adding culture medium. A subcultivation ratio of 1:6 to 1:8 is recommended.
8) Transfer the cell suspension to new 100mm dish and Incubate the cells in 37°C, 5% CO2 incubator.
9) Replace the medium with fresh pre-warmed culture medium every 2 to 3 days.
10) Culture the cells until the required density (70 -90% of confluent; Fig 1, C) is reached.

Citations for GIST-T1 Cell Line – 58 Found

Campanella, Nathália Cristina; Gomes, Izabela Natalia Faria; Alves, Ana Laura Vieira; Leal, Leticia Ferro; Evangelista, Adriane Feijó; Rosa, Marcela Nunes; Melendez, Matias Eliseo; Silva, Viviane Aline Oliveira; Dias, Richard Lucas Konichi; Abrahão-Machado, Lucas Faria; Santana, Iara; Martinho, Olga; Guimarães, Denise Peixoto; Faça, Vitor Marcel; Reis, Rui Manuel. Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis. Cancer Cell International. 2023;23(1):256. 
- Comments: Cosmo Bio’s GIST-T1 cells were used in a study demonstrating that knockout of RKIP increased the invasion and migration potential of gastrointestinal stromal tumor cells and reduced their responsiveness to Imatinib treatment.

Mehra, Dushyant; Pucher, Elias M. Correction Notice: Correlative Conventional and Super-resolution Photoactivated Localization Microscopy (PALM) Imaging to Characterize Chromatin Structure and Dynamics in Live Mammalian Cells. Bio-Protocol. 2023;13(21):e4896. 
- Comments: Cosmo Bio’s GIST-T1 cells were used in this fluorescence super-resolution microscopy protocol for exploring the spatial organization and dynamics of chromatin. GIST-T1 cells were chosen because their cancer phenotype is hypothesized to be impacted by changes in chromatin structure and because living GIST-T1 cells can be imaged for long periods of time while exhibiting minimal auto-fluorescence and cell death.

Sun, Xiangfei; Zhang, Qiang; Lin, Xiaohan; Shu, Ping; Gao, Xiaodong; Shen, Kuntang. Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination. Cell Death & Disease. 2023;14(12):839. 
- Comments: Cosmo Bio’s GIST-T1 cells were used in a study demonstrating that tyrosine kinase inhibitor imatinib (IM) induces ferroptosis by promoting STUB1-mediated glutathione peroxidase 4 (GPX4) ubiquitination in gastrointestinal stromal tumors (GIST) and revealing a synergistic effect of IM combined with GPX4 inhibitor (RSL3) in treating GIST.

Wu, Xiyu; Iwatsuki, Masaaki; Takaki, Masakazu; Saito, Takuro; Hayashi, Tsutomu; Kondo, Masato; Sakai, Yoshiharu; Gotohda, Naoto; Tanaka, Eiji; Nishida, Toshirou; Baba, Hideo. FBXW7 regulates the sensitivity of imatinib in gastrointestinal stromal tumors by targeting MCL1. Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association. 2024;27(2):235-247. 

Takaki, Emiri Omori; Kiyono, Kunihiko; Obuchi, Yutaka; Yamauchi, Takeshi; Watanabe, Takashi; Matsumoto, Hideki; Karimine, Miho; Kuniyoshi, Yuki; Nishikori, Shingo; Yokoyama, Fumiharu; Nishimori, Hikaru; Nabeshima, Hiroshi; Nakamura, Kazuhide. A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research. 2024; 38864850( 38864850) 

Gloazzo, Simona; Sbaraglia, Marta; Bellan, Elena; Gasparotto, Daniela; Belli, Elena; Baldazzi, Davide; Rossi, Gabriella; Magnani, Elena; Rosito, Maria Pia; Carnevali, Andrea; Piccinin, Sara; Dei Tos, Angelo Paolo; Maestro, Roberta. KIT Mutation-NTRK fusion oncogenic driver switch: a novel mechanism of acquired imatinib resistance in GIST. Npj Precision Oncology. 2026;10(1) 

Sun, Xiangfei; Sun, Yinwen; Shu, Ping; Yi, Tuo; Shen, Kuntang; Niu, Weixin; Hong, Xinqiang. Long Non-Coding RNA CTD-2245E15.3 Drives Proliferation and Migration in Gastrointestinal Stromal Tumors. Biomedicines. 2026;14(3) 

Zhang, Liangying; Xiao, Kun; Zhang, Shaoting; Zhao, Sien; Liu, Zimei; Wang, Ming; Qin, Kaiyue; Yu, Yuanyuan; Li, Shujing; Ma, Lijun; Sun, Jianmin. SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation. Scientific Reports. 2025;15(1):4779. 

He, Chunxiao; Yu, Jiaying; Mao, Shuang; Yang, Shaohua; Jiang, Xianming; Huang, Lei; Li, Mingzhe; He, Yulong; Zhang, Xinhua; Xiang, Xi. SHP2 inhibition and adjuvant therapy synergistically target KIT-mutant GISTs via ERK1/2-regulated GSK3β/cyclin D1 pathway. Clinical And Translational Medicine. 2025;15(2):e70231. 

Obata, Yuuki; Natsume, Miyuki; Shiina, Isamu; Takahashi, Tsuyoshi; Nishida, Toshirou. Golgi retention of KIT in gastrointestinal stromal tumour cells is phospholipase D activity-dependent. Scientific Reports. 2025;15(1):28778. 

Konate, Karidia; Pezzati, Irène; Redjatti, Karima; Agnel, Estelle; Vivès, Eric; Faure, Sandrine; de Santa Barbara, Pascal; Boisguérin, Prisca; Deshayes, Sébastien. Multiprotein Silencing Using WRAP-Based Nanoparticles: A Proof of Concept. Bioconjugate Chemistry. 2025;36(6):1218-1233. 

Natsume, Miyuki; Niwa, Mariko; Ichikawa, Sho; Okamoto, Takuma; Tsutsui, Hisazumi; Usukura, Daiki; Murata, Takatsugu; Abe, Ryo; Shimonaka, Motoyuki; Nishida, Toshirou; Shiina, Isamu; Obata, Yuuki. Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5. The Journal Of Biological Chemistry. 2024;300(6):107327. 

Kim, Kyung Lock; Rahme, Gilbert J; Goel, Viraat Y; El Farran, Chadi A; Hansen, Anders S; Bernstein, Bradley E. Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation. Molecular Cell. 2024;84(7):1365-1376.e7. 

He, Bo; Dymond, Larissa; Wood, Kira H; Bastow, Edward R; Satiaputra, Jiulia; Li, Ji; Johansson-Percival, Anna; Hamzah, Juliana; Kumarasinghe, M Priyanthi; Ballal, Mohammed; Foo, Jonathan; Johansson, Mikael; Ee, Hooi C; White, Scott W; Winteringham, Louise; Ganss, Ruth. Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor. Oncoimmunology. 13(1):2406576. 

Zhaorigetu et., al. . CircRNA amyloid precursor protein by competitive adsorption of microRNA-6838-5p mediates CDV3 expression to enhance malignant behavior and Warburg effect in Gastrointestinal Stromal Tumor. Clinics. 2024;79:100423. 

Ruiz-Demoulin, Salomé; Trenquier, Eva; Dekkar, Sanaa; Deshayes, Sébastien; Boisguérin, Prisca; Serrano, César; de Santa Barbara, Pascal; Faure, Sandrine. LIX1 Controls MAPK Signaling Reactivation and Contributes to GIST-T1 Cell Resistance to Imatinib. International Journal Of Molecular Sciences. 2023;24(8) 

Huang, Chen; Wang, Ming; Zhao, Wen-Yi; Shen, Yan-Ying; Zhuang, Chun; Ni, Bo; Yang, Lin-Xi; Lu, Lu; Li, Xiao-Qi; Tu, Lin; Cao, Hui. Long noncoding RNA SPRY4-IT1 acts as a miR-101-5p sponge to promote gastrointestinal stromal tumor progression by inhibiting ZEB1. American Journal Of Translational Research. 15(2):1026-1040. 

Obata, Yuuki; Kurokawa, Kazuo; Tojima, Takuro; Natsume, Miyuki; Shiina, Isamu; Takahashi, Tsuyoshi; Abe, Ryo; Nakano, Akihiko; Nishida, Toshirou. Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells. Cell Reports. 2023;42(9):113035. 

Yan, Jingyi; Chen, Xiaolei; Lin, Ji; Sun, Xuecheng; Chen, Wei. LncRNA HIF1A-AS2 mediates imatinib resistance by regulating autophagy in gastrointestinal stromal tumor cells. Neoplasma. 2023;70(4):526-533. 

Li, Shujing; Zhao, Sien; Liang, Nianhai; Zhang, Shaoting; Zhang, Liangying; Zhou, Liangji; Liu, Anbu; Cao, Xu; Tian, Jinhai; Yu, Yuanyuan; Fan, Zhaoyang; Xiao, Kun; Wang, Ming; Zhao, Hui; Bai, Ru; Sun, Jianmin. SPRY4 inhibits and sensitizes the primary KIT mutants in gastrointestinal stromal tumors (GISTs) to imatinib. Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association. 2023;26(5):677-690. 

Chen, Sijun; Wu, Feijing; Zhang, Jiaxuan; Zhu, Jianwei; Zhou, Xiaorong; Zhi, Xiaofei. ADRB2 Regulates the Proliferation and Metastasis of Gastrointestinal Stromal Tumor Cells by Enhancing the ETV1-c-KIT Signaling. Journal Of Oncology. 2023:6413796. 

Hemming, Matthew L; Benson, Morgan R; Loycano, Michael A; Anderson, Justin A; Andersen, Jessica L; Taddei, Madeleine L; Krivtsov, Andrei V; Aubrey, Brandon J; Cutler, Jevon A; Hatton, Charlie; Sicinska, Ewa; Armstrong, Scott A. MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor. Cancer Discovery. 2022;12(7):1804-1823. 

Yuan, Jiayin; Kihara, Takako; Kimura, Neinei; Yamasaki, Takashi; Yoshida, Makoto; Isozaki, Koji; Ito, Akihiko; Hirota, Seiichi. CADM1 promotes adhesion to vascular endothelial cells and transendothelial migration in cultured GIST cells. Oncology Letters. 2022;23(3):86. 

Pulkka, Olli-Pekka; Viisanen, Leevi; Tynninen, Olli; Laaksonen, Maria; Reichardt, Peter; Reichardt, Annette; Eriksson, Mikael; Hall, Kirsten Sundby; Wardelmann, Eva; Nilsson, Bengt; Sihto, Harri; Joensuu, Heikki. Fibrinogen-like protein 2 in gastrointestinal stromal tumour. Journal Of Cellular And Molecular Medicine. 2022;26(4):1083-1094. 

Shima, Takafumi; Taniguchi, Kohei; Tokumaru, Yoshihisa; Inomata, Yosuke; Arima, Jun; Lee, Sang-Woong; Takabe, Kazuaki; Yoshida, Kazuhiro; Uchiyama, Kazuhisa. Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells. Oncology Reports. 2022;47(1) 

Sun, Jianyi; Zhang, Qiang; Sun, Xiangfei; Xue, Anwei; Gao, Xiaodong; Shen, Kuntang. THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours. Cell Communication And Signaling : Ccs. 2022;20(1):138. 

Liu, Juan; Gao, Jingjing; Wang, Aoli; Jiang, Zongru; Qi, Shuang; Qi, Ziping; Liu, Feiyang; Yu, Kailin; Cao, Jiangyan; Chen, Cheng; Hu, Chen; Wu, Hong; Wang, Li; Wang, Wenchao; Liu, Qingsong; Liu, Jing. Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib-induced KIT mutations in gastrointestinal stromal tumours. Molecular Oncology. 2022;16(8):1761-1774. 

Mehra, Dushyant; Adhikari, Santosh; Banerjee, Chiranjib; Puchner, Elias M. Characterizing locus specific chromatin structure and dynamics with correlative conventional and super-resolution imaging in living cells. Nucleic Acids Research. 2022;50(13):e78. 

Niinuma, Takeshi; Kitajima, Hiroshi; Yamamoto, Eiichiro; Maruyama, Reo; Aoki, Hironori; Harada, Taku; Ishiguro, Kazuya; Sudo, Gota; Toyota, Mutsumi; Yoshido, Ayano; Kai, Masahiro; Nakase, Hiroshi; Sugai, Tamotsu; Suzuki, Hiromu. An Integrated Epigenome and Transcriptome Analysis to Clarify the Effect of Epigenetic Inhibitors on GIST. Anticancer Research. 2021;41(6):2817-2828. 

Sasaki, Makiko; Tanaka, Mamoru; Ichikawa, Hiroshi; Suzuki, Taketo; Nishie, Hirotada; Ozeki, Keiji; Shimura, Takaya; Kubota, Eiji; Tanida, Satoshi; Kataoka, Hiromi. 5-aminolaevulinic acid (5-ALA) accumulates in GIST-T1 cells and photodynamic diagnosis using 5-ALA identifies gastrointestinal stromal tumors (GISTs) in xenograft tumor models. Plos One. 16(4):e0249650. 

Leng, Yun; Zhao, Can; Yan, Guoliang; Xu, Shuangyue; Yang, Yinggui; Gong, Ting; Li, Xin; Li, Chenglin. Ghrelin enhances cisplatin sensitivity in HO-8910 PM human ovarian cancer cells. Journal Of Ovarian Research. 2021;14(1):162. 

Zhang, Jinyan; Chen, Ke; Tang, Yuexiao; Luan, Xiaorui; Zheng, Xiaoxiao; Lu, Xuemei; Mao, Jiayan; Hu, Liqiang; Zhang, Shufen; Zhang, Xianning; Chen, Wei. LncRNA-HOTAIR activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the miR-130a/ATG2B pathway. Cell Death & Disease. 2021;12(4):367. 

Huang, Wen-Kuan; Shi, Hao; Akçakaya, Pinar; Zeljic, Katarina; Gangaev, Anastasia; Caramuta, Stefano; Yeh, Chun-Nan; Bränström, Robert; Larsson, Catharina; Lui, Weng-Onn. Imatinib Regulates miR-483-3p and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors. International Journal Of Molecular Sciences. 2021;22(19) 

Sellberg, Felix; Fröbom, Robin; Binder, Christian; Berglund, Erik; Berglund, David. Polyvinyl Alcohol Carbazate as a Polymer-Based Antitumoral Agent. Frontiers In Oncology. 10:598394. 

Hemming, Matthew L; Coy, Shannon; Lin, Jia-Ren; Andersen, Jessica L; Przybyl, Joanna; Mazzola, Emanuele; Abdelhamid Ahmed, Amr H; van de Rijn, Matt; Sorger, Peter K; Armstrong, Scott A; Demetri, George D; Santagata, Sandro. HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research. 2021;27(6):1706-1719. 

Huang, Wen-Kuan; Gao, Jiwei; Chen, Ziqing; Shi, Hao; Yuan, Juan; Cui, Huanhuan L; Yeh, Chun-Nan; Bränström, Robert; Larsson, Catharina; Li, Shuijie; Lui, Weng-Onn. Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal Tumor. Cells. 2020;9(6) 

Gyvyte, Ugne; Lukosevicius, Rokas; Inciuraite, Ruta; Streleckiene, Greta; Gudoityte, Greta; Bekampyte, Justina; Valentini, Serena; Salteniene, Violeta; Ruzgys, Paulius; Satkauskas, Saulius; Zviniene, Kristina; Kupcinskas, Juozas; Skieceviciene, Jurgita. The Role of miR-375-3p and miR-200b-3p in Gastrointestinal Stromal Tumors. International Journal Of Molecular Sciences. 2020;21(14) 

Gao, Xiaodong; Ma, Chunmin; Sun, Xiangwei; Zhao, Qin; Fang, Yong; Jiang, Yuhui; Shen, Kuntang; Shen, Xian. Upregulation of ZNF148 in SDHB-deficient gastrointestinal stromal tumor potentiates Forkhead box M1-mediated transcription and promotes tumor cell invasion. Cancer Science. 2020;111(4):1266-1278. 

Weng, Xiaoyuan; Zheng, Song; Shui, Hanli; Lin, Guosheng; Zhou, Yongjian. TUFM-knockdown inhibits the migration and proliferation of gastrointestinal stromal tumor cells. Oncology Letters. 2020;20(5):250. 

Guérin, Amandine; Martire, Delphine; Trenquier, Eva; Lesluyes, Tom; Sagnol, Sébastien; Pratlong, Marine; Lefebvre, Elise; Chibon, Fréderic; de Santa Barbara, Pascal; Faure, Sandrine. LIX1 regulates YAP activity and controls gastrointestinal cancer cell plasticity. Journal Of Cellular And Molecular Medicine. 2020;24(16):9244-9254. 

Kobara, Hideki; Fujihara, Shintaro; Iwama, Hisakazu; Matsui, Takanori; Fujimori, Ayako; Chiyo, Taiga; Tingting, Shi; Kobayashi, Nobuya; Nishiyama, Noriko; Yachida, Tatsuo; Tadokoro, Tomoko; Oura, Kyoko; Tani, Joji; Fujita, Koji; Nomura, Takako; Yoneyama, Hirohito; Morishita, Asahiro; Okano, Keiichi; Suzuki, Yasuyuki; Mori, Hirohito; Masaki, Tsutomu. Antihypertensive drug telmisartan inhibits cell proliferation of gastrointestinal stromal tumor cells in vitro. Molecular Medicine Reports. 2020;22(2):1063-1071. 

Funasaka, Kohei; Miyahara, Ryoji; Furukawa, Kazuhiro; Sawada, Tsunaki; Maeda, Keiko; Yamamura, Takeshi; Ishikawa, Takuya; Ohno, Eizaburo; Nakamura, Masanao; Kawashima, Hiroki; Hirooka, Yoshiki; Ohmiya, Naoki; Fujishiro, Mitsuhiro. Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration. Translational Oncology. 2020;13(11):100848. 

Obata, Yuuki; Hara, Yasushi; Shiina, Isamu; Murata, Takatsugu; Tasaki, Yasutaka; Suzuki, Kyohei; Ito, Keiichi; Tsugawa, Shou; Yamawaki, Kouhei; Takahashi, Tsuyoshi; Okamoto, Koji; Nishida, Toshirou; Abe, Ryo. N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells. Cell Communication And Signaling : Ccs. 2019;17(1):114. 

Liu, Feiyang; Zou, Fengming; Chen, Cheng; Yu, Kailin; Liu, Xiaochuan; Qi, Shuang; Wu, Jiaxin; Hu, Chen; Hu, Zhenquan; Liu, Juan; Liu, Xuesong; Wang, Li; Ge, Juan; Wang, Wenchao; Ren, Tao; Bai, Mingfeng; Cai, Yujiao; Xiao, Xudong; Qian, Feng; Tang, Jun; Liu, Qingsong; Liu, Jing. Axitinib overcomes multiple imatinib resistant cKIT mutations including the gatekeeper mutation T670I in gastrointestinal stromal tumors. Therapeutic Advances In Medical Oncology. 11:1758835919849757. 

Hsueh, Yuan-Shuo; Chang, Hui Hua; Shan, Yan-Shen; Sun, H Sunny; Fletcher, Jonathan Alfred; Li, Chien-Feng; Chen, Li-Tzong. Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors. Oncogene. 2019;38(38):6550-6565. 

Wang, Huizhen; Zhang, Xin. ROS Reduction Does Not Decrease the Anticancer Efficacy of X-Ray in Two Breast Cancer Cell Lines. Oxidative Medicine And Cellular Longevity. 2019:3782074. 

Hemming, Matthew L; Lawlor, Matthew A; Andersen, Jessica L; Hagan, Timothy; Chipashvili, Otari; Scott, Thomas G; Raut, Chandrajit P; Sicinska, Ewa; Armstrong, Scott A; Demetri, George D; Bradner, James E. Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Cancer Research. 2019;79(5):994-1009. 

Wang, Ming; Ni, Bo; Zhuang, Chun; Zhao, Wen-Yi; Tu, Lin; Ma, Xin-Li; Yang, Lin-Xi; Zhang, Zhi-Gang; Cao, Hui. Aberrant accumulation of Dickkopf 4 promotes tumor progression via forming the immune suppressive microenvironment in gastrointestinal stromal tumor. Cancer Medicine. 2019;8(11):5352-5366. 

Koga, Yuki; Iwatsuki, Masaaki; Yamashita, Kohei; Kiyozumi, Yuki; Kurashige, Junji; Masuda, Toshiro; Eto, Kojiro; Iwagami, Shiro; Harada, Kazuto; Ishimoto, Takatsugu; Baba, Yoshifumi; Yoshida, Naoya; Miyanari, Nobutomo; Takamori, Hiroshi; Ajani, Jaffer A; Baba, Hideo. The role of FBXW7, a cell-cycle regulator, as a predictive marker of recurrence of gastrointestinal stromal tumors. Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association. 2019;22(6):1100-1108. 

Fröbom, Robin; Sellberg, Felix; Xu, Cheng; Zhao, Allan; Larsson, Catharina; Lui, Wenn-Onn; Nilsson, Inga-Lena; Berglund, Erik; Bränström, Robert. Biochemical Inhibition of DOG1/TMEM16A Achieves Antitumoral Effects in Human Gastrointestinal Stromal Tumor Cells In Vitro. Anticancer Research. 2019;39(7):3433-3442. 

Flavahan, William A; Drier, Yotam; Johnstone, Sarah E; Hemming, Matthew L; Tarjan, Daniel R; Hegazi, Esmat; Shareef, Sarah J; Javed, Nauman M; Raut, Chandrajit P; Eschle, Benjamin K; Gokhale, Prafulla C; Hornick, Jason L; Sicinska, Ewa T; Demetri, George D; Bernstein, Bradley E. Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs. Nature. 2019;575(7781):229-233. 

Pulkka, Olli-Pekka; Mpindi, John-Patrick; Tynninen, Olli; Nilsson, Bengt; Kallioniemi, Olli; Sihto, Harri; Joensuu, Heikki. Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours. Journal Of Cellular And Molecular Medicine. 2018;22(4):2220-2230. 

Xiaofei Tian et., al.. Magnetic field direction differentially impacts the growth of different cell types. Electromagnetic Biology and Medicine. 2018;37(2) 

Inagaki, Yusuke; Kubota, Eiji; Mori, Yoshinori; Aoyama, Mineyoshi; Kataoka, Hiromi; Johnston, Randal N; Joh, Takashi. Anti-tumor efficacy of oncolytic reovirus against gastrointestinal stromal tumor cells. Oncotarget. 2017;8(70):115632-115646. 

Wong, Meihong; Funasaka, Kohei; Obayashi, Tomohiko; Miyahara, Ryoji; Hirooka, Yoshiki; Hamaguchi, Michinari; Goto, Hidemi; Senga, Takeshi. AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors. Oncology Letters. 2017;13(3):1281-1287. 

Gao, Xiaodong; Xue, Anwei; Fang, Yong; Shu, Ping; Ling, Jiaqian; Hou, Yingyong; Shen, Kuntang; Qin, Jing; Sun, Yihong; Qin, Xinyu. RACK1 overexpression is linked to acquired imatinib resistance in gastrointestinal stromal tumor. Oncotarget. 2016;7(12):14300-9. 

Cao, C-L; Niu, H-J; Kang, S-P; Cong, C-L; Kang, S-R. miRNA-21 sensitizes gastrointestinal stromal tumors (GISTs) cells to Imatinib via targeting B-cell lymphoma 2 (Bcl-2). European Review For Medical And Pharmacological Sciences. 2016;20(17):3574-81. 

Lee, Na Keum; Lee, Jung Hwa; Kim, Won Kyu; Yun, Seongju; Youn, Young Hoon; Park, Chan Hyuk; Choi, Yun Young; Kim, Hogeun; Lee, Sang Kil. Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors. Oncotarget. 2016;7(46):75307-75318. 

Documentation Requirements for Order Placement

Material Transfer or Licensing Agreement (MTA)
The manufacturer of this product requires a signed Material Transfer or Licensing Agreement to be submitted at time of order placement. Access the agreement in the Documents section above. Please download and fill in the document as requested. Submit the completed document with your order to orders@cosmobiousa.com.

Direct Shipment and Fees Authorization
This item must ship directly from our Japan office due to permit requirements, temperature sensitivity, or other shipping considerations. Access the direct shipment authorization form in the Documents section above. Please download and fill in the document as requested. Submit the completed document with your order to orders@cosmobiousa.com.