Anti TACC3 mAb (Clone 10G7)

CUSABIO

Catalog No.:
CSB-RA553945A0HU-50
Western Blot<br /> Positive WB detected in: K562 whole cell lysate, THP-1 whole cell lysate<br /> All lanes: TACC3 Antibody at 1:1000<br /> Secondary<br /> Goat polyclonal to rabbit IgG at 1/50000 dilution<br /> Predicted band size: 91 kDa<br /> Observed band size: 140 kDa<br />
IHC image of CSB-RA553945A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
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Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).

Product Specifications
Application WB, IHC, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 10G7)

Documents & Links for Anti TACC3 mAb (Clone 10G7)
Datasheet Anti TACC3 mAb (Clone 10G7) Datasheet

Documents & Links for Anti TACC3 mAb (Clone 10G7)
Datasheet Anti TACC3 mAb (Clone 10G7) Datasheet
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