Anti-SynCAM (TSLC1/CADM1) (Human) mAb (Clone: 3E1)

MBL Life Sciences

Catalog No.: MBL-CM004-3

Product Description

Monoclonal antibody of 100 µl targeting TSLC1/CADM1.

Background

SynCAM (Synaptic Cell Adhesion Molecule), also known as TSLC1 (tumor suppressor in lung cancer-1), SgIGSF, or CADM1, is a homophilic, transmembrane Ig-domain containing protein with intracellular PDZ protein-binding motifs. Although originally identified as a tumor suppressor of small lung cell carcinomas, SynCAM appears to be primarily involved in intracellular adhesion and synapse formation. The majority of SynCAM is localized to synaptic sites where it initiates synaptic assembly and synapse differentiation throughout the central nervous system. SynCAM also mediates the cellular adhesion of spermatogenic cells to Sertoli cells and mast cells to fibroblasts.

Product Specifications

• Application: FC, ICC, IP, WB, IHC
• Reactivity: Human, Mouse, Rat, Porcine, Equine
• Clonality: Monoclonal IgY
• Host: Chicken
• Immunogen: Recombinant fusion protein Fc-SynCAM
• Gene ID - Human:

  23705

• Gene ID - Mouse:

  54725

• Formulation: 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
• Storage: -20C

Citations for Anti-SynCAM (TSLC1/CADM1) (Human) mAb (Clone: 3E1) – 28 Found

Yang, Weidong; Kaur, Davinder; Okayama, Yoshimichi; Ito, Akihiko; Wardlaw, Andrew J; Brightling, Christopher E; Bradding, Peter. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. Journal Of Immunology (Baltimore, Md. : 1950). 2006;176(2):1238-43. 
- Comments: Used in: FCM

Yang, Weidong; Kaur, Davinder; Okayama, Yoshimichi; Ito, Akihiko; Wardlaw, Andrew J; Brightling, Christopher E; Bradding, Peter. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. Journal Of Immunology (Baltimore, Md. : 1950). 2006;176(2):1238-43. 
- Comments: Used in: ICC

Wakayama, Tomohiko; Sai, Yoshimichi; Ito, Akihiko; Kato, Yukio; Kurobo, Miho; Murakami, Yoshinori; Nakashima, Emi; Tsuji, Akira; Kitamura, Yukihiko; Iseki, Shoichi. Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells. Biology Of Reproduction. 2007;76(6):1081-90. 
- Comments: Used in: ICC

Fogel, Adam I; Akins, Michael R; Krupp, Alexander J; Stagi, Massimiliano; Stein, Valentin; Biederer, Thomas. SynCAMs organize synapses through heterophilic adhesion. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. 2007;27(46):12516-30. 
- Comments: Used in: WB

Fogel, Adam I; Akins, Michael R; Krupp, Alexander J; Stagi, Massimiliano; Stein, Valentin; Biederer, Thomas. SynCAMs organize synapses through heterophilic adhesion. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. 2007;27(46):12516-30. 
- Comments: Used in: IP

Fujita, Eriko; Tanabe, Yuko; Hirose, Tomonori; Aurrand-Lions, Michel; Kasahara, Tadashi; Imhof, Beat A; Ohno, Shigeo; Momoi, Takashi. Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. The American Journal Of Pathology. 2007;171(6):1800-10. 
- Comments: Used in: IHC

Hollins, Fay; Kaur, Davinder; Yang, Weidong; Cruse, Glenn; Saunders, Ruth; Sutcliffe, Amanda; Berger, Patrick; Ito, Akihiko; Brightling, Christopher E; Bradding, Peter. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. Journal Of Immunology (Baltimore, Md. : 1950). 2008;181(4):2772-80. 
- Comments: Used in: IP

Hollins, Fay; Kaur, Davinder; Yang, Weidong; Cruse, Glenn; Saunders, Ruth; Sutcliffe, Amanda; Berger, Patrick; Ito, Akihiko; Brightling, Christopher E; Bradding, Peter. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. Journal Of Immunology (Baltimore, Md. : 1950). 2008;181(4):2772-80. 
- Comments: Used in: ICC

Hagiyama, Man; Ichiyanagi, Naoki; Kimura, Keiko B; Murakami, Yoshinori; Ito, Akihiko. Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth. The American Journal Of Pathology. 2009;174(6):2278-89. 
- Comments: Used in: WB

Hagiyama, Man; Ichiyanagi, Naoki; Kimura, Keiko B; Murakami, Yoshinori; Ito, Akihiko. Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth. The American Journal Of Pathology. 2009;174(6):2278-89. 
- Comments: Used in: IP

Hasstedt, Sandra J; Bezemer, Irene D; Callas, Peter W; Vossen, Carla Y; Trotman, Winifred; Hebbel, Robert P; Demers, Christine; Rosendaal, Frits R; Bovill, Edwin G. Cell adhesion molecule 1: a novel risk factor for venous thrombosis. Blood. 2009;114(14):3084-91. 
- Comments: Used in: IHC

Gao, Ying; Lui, Wing-Yee. Transforming growth factor-β1 (TGF-β1) regulates cell junction restructuring via Smad-mediated repression and clathrin-mediated endocytosis of nectin-like molecule 2 (Necl-2). Plos One. 8(5):e64316. 
- Comments: Used in: WB

Ribic, Adema; Liu, Xinran; Crair, Michael C; Biederer, Thomas. Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. The Journal Of Comparative Neurology. 2014;522(4):900-20. 
- Comments: Used in: WB

Ribic, Adema; Liu, Xinran; Crair, Michael C; Biederer, Thomas. Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. The Journal Of Comparative Neurology. 2014;522(4):900-20. 
- Comments: Used in: IHC

Nikitczuk, Jessica S; Patil, Shekhar B; Matikainen-Ankney, Bridget A; Scarpa, Joseph; Shapiro, Matthew L; Benson, Deanna L; Huntley, George W. N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo. Hippocampus. 2014;24(8):943-962. 
- Comments: Used in: WB

Cheadle, Lucas; Biederer, Thomas. Activity-dependent regulation of dendritic complexity by semaphorin 3A through Farp1. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. 2014;34(23):7999-8009. 
- Comments: Used in: WB

Zhang, Charles; Caldwell, Thomas A; Mirbolooki, M Reza; Duong, Diana; Park, Eun Jee; Chi, Nai-Wen; Chessler, Steven D. Extracellular CADM1 interactions influence insulin secretion by rat and human islet β-cells and promote clustering of syntaxin-1. American Journal Of Physiology. Endocrinology And Metabolism. 2016;310(11):E874-85. 
- Comments: Used in: FCM

Park, Kellie A; Ribic, Adema; Laage Gaupp, Fabian M; Coman, Daniel; Huang, Yuegao; Dulla, Chris G; Hyder, Fahmeed; Biederer, Thomas. Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. 2016;36(28):7464-75. 
- Comments: Used in: IHC

Ziegler, Anja; Marti, Eliane; Summerfield, Artur; Baumann, Arnaud. Identification and characterization of equine blood plasmacytoid dendritic cells. Developmental And Comparative Immunology. 2016;65:352-357. 
- Comments: Used in: FCM

Rademacher, Nils; Schmerl, Bettina; Lardong, Jennifer A; Wahl, Markus C; Shoichet, Sarah A. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Scientific Reports. 2016;6:35283. 
- Comments: Used in: ICC

Rathjen, Thomas; Yan, Xin; Kononenko, Natalia L; Ku, Min-Chi; Song, Kun; Ferrarese, Leiron; Tarallo, Valentina; Puchkov, Dmytro; Kochlamazashvili, Gaga; Brachs, Sebastian; Varela, Luis; Szigeti-Buck, Klara; Yi, Chun-Xia; Schriever, Sonja C; Tattikota, Sudhir Gopal; Carlo, Anne Sophie; Moroni, Mirko; Siemens, Jan; Heuser, Arnd; van der Weyden, Louise; Birkenfeld, Andreas L; Niendorf, Thoralf; Poulet, James F A; Horvath, Tamas L; Tschöp, Matthias H; Heinig, Matthias; Trajkovski, Mirko; Haucke, Volker; Poy, Matthew N. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nature Neuroscience. 2017;20(8):1096-1103. 
- Comments: Used in: WB

Rathjen, Thomas; Yan, Xin; Kononenko, Natalia L; Ku, Min-Chi; Song, Kun; Ferrarese, Leiron; Tarallo, Valentina; Puchkov, Dmytro; Kochlamazashvili, Gaga; Brachs, Sebastian; Varela, Luis; Szigeti-Buck, Klara; Yi, Chun-Xia; Schriever, Sonja C; Tattikota, Sudhir Gopal; Carlo, Anne Sophie; Moroni, Mirko; Siemens, Jan; Heuser, Arnd; van der Weyden, Louise; Birkenfeld, Andreas L; Niendorf, Thoralf; Poulet, James F A; Horvath, Tamas L; Tschöp, Matthias H; Heinig, Matthias; Trajkovski, Mirko; Haucke, Volker; Poy, Matthew N. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nature Neuroscience. 2017;20(8):1096-1103. 
- Comments: Used in: IHC

Braun, Roman Othmar; Python, Sylvie; Summerfield, Artur. Porcine B Cell Subset Responses to Toll-like Receptor Ligands. Frontiers In Immunology. 8:1044. 
- Comments: Used in: FCM

Balan, Sreekumar; Arnold-Schrauf, Catharina; Abbas, Abdenour; Couespel, Norbert; Savoret, Juliette; Imperatore, Francesco; Villani, Alexandra-Chloé; Vu Manh, Thien-Phong; Bhardwaj, Nina; Dalod, Marc. Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity. Cell Reports. 2018;24(7):1902-1915.e6. 
- Comments: Used in: FCM

Oka, Takashi; Mizuno, Hajime; Sakata, Masumi; Fujita, Hirofumi; Yoshino, Tadashi; Yamano, Yoshihisa; Utsumi, Kozo; Masujima, Tsutomu; Utsunomiya, Atae. Metabolic abnormalities in adult T-cell leukemia/lymphoma and induction of specific leukemic cell death using photodynamic therapy. Scientific Reports. 2018;8(1):14979. 
- Comments: Used in: FCM

Parra-Sánchez, Héctor; Bustamante-Córdova, Lorena; Reséndiz, Mónica; Mata-Haro, Verónica; Pinelli-Saavedra, Araceli; Hernández, Jesús. Analysis of Swine Conventional Dendritic Cells, DEC205(+)CD172a(+/-)CADM1(+), from Blood and Spleen in Response to PRRSV and PEDV. Viruses. 2019;11(11) 
- Comments: Used in: FCM

Nakahata, Shingo; Syahrul, Chilmi; Nakatake, Ayako; Sakamoto, Kuniyo; Yoshihama, Maki; Nishikata, Ichiro; Ukai, Yoshinori; Matsuura, Tadashi; Kameda, Takuro; Shide, Kotaro; Kubuki, Yoko; Hidaka, Tomonori; Kitanaka, Akira; Ito, Akihiko; Takemoto, Shigeki; Nakano, Nobuaki; Saito, Masumichi; Iwanaga, Masako; Sagara, Yasuko; Mochida, Kosuke; Amano, Masahiro; Maeda, Kouichi; Sueoka, Eisaburo; Okayama, Akihiko; Utsunomiya, Atae; Shimoda, Kazuya; Watanabe, Toshiki; Morishita, Kazuhiro. Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma. Haematologica. 2021;106(2):532-542. 
- Comments: Used in: ELISA

Bustamante-Córdova, Lorena; Melgoza-González, Edgar Alonso; Parra-Sánchez, Héctor; Reséndiz-Sandoval, Mónica; Burgara-Estrella, Alexel Jesús; Hernández, Jesús. Production of a full chimeric mouse x pig anti-porcine DEC205 receptor recombinant antibody. Journal Of Immunological Methods. 2021;489:112911. 
- Comments: Used in: FCM