Anti PTPN11 mAb (Clone 6G11)

CUSABIO

SKU:
CSB-RA289762A0HU-50
  • Western Blot<br /> Positive WB detected in: Jurkat whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate, Hela whole cell lysate, K562 whole cell lysate, HL60 whole cell lysate<br /> All lanes: PTPN11 antibody at 1:2000<br /> Secondary<br /> Goat polyclonal to rabbit IgG at 1/50000 dilution<br /> Predicted band size: 69, 53 kDa<br /> Observed band size: 69 kDa<br />
  • IHC image of CSB-RA289762A0HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
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Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).

Product Specifications
Application WB, IHC, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 6G11)


Documents & Links for Anti PTPN11 mAb (Clone 6G11)
Datasheet Anti PTPN11 mAb (Clone 6G11) Datasheet

Documents & Links for Anti PTPN11 mAb (Clone 6G11)
Datasheet Anti PTPN11 mAb (Clone 6G11) Datasheet



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