Anti PPHLN1 pAb (ATL-HPA038902 w/enhanced validation)

Atlas Antibodies

Catalog No.: ATL-HPA038902-25

Protein Description: periphilin 1
Gene Name: PPHLN1
Alternative Gene Name:
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000036167: 83%, ENSRNOG00000022778: 83%
Entrez Gene ID: 51535
Uniprot ID: Q8NEY8
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: ICC, IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: KKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDRRSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSR
• Gene Sequence: KKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDRRSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSR
• Gene ID - Mouse: ENSMUSG00000036167
• Gene ID - Rat: ENSRNOG00000022778
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti PPHLN1 pAb (ATL-HPA038902 w/enhanced validation) – 5 Found

Tchasovnikarova, Iva A; Timms, Richard T; Matheson, Nicholas J; Wals, Kim; Antrobus, Robin; Göttgens, Berthold; Dougan, Gordon; Dawson, Mark A; Lehner, Paul J. GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Science (New York, N.y.). 2015;348(6242):1481-1485. 

Yurkovetskiy, Leonid; Guney, Mehmet Hakan; Kim, Kyusik; Goh, Shih Lin; McCauley, Sean; Dauphin, Ann; Diehl, William E; Luban, Jeremy. Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex. Nature Microbiology. 2018;3(12):1354-1361. 

Yan, Junpeng; Shun, Ming-Chieh; Zhang, Yi; Hao, Caili; Skowronski, Jacek. HIV-1 Vpr counteracts HLTF-mediated restriction of HIV-1 infection in T cells. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2019;116(19):9568-9577. 

Seczynska, Marta; Bloor, Stuart; Cuesta, Sergio Martinez; Lehner, Paul J. Genome surveillance by HUSH-mediated silencing of intronless mobile elements. Nature. 2022;601(7893):440-445. 

Tunbak, Hale; Enriquez-Gasca, Rocio; Tie, Christopher H C; Gould, Poppy A; Mlcochova, Petra; Gupta, Ravindra K; Fernandes, Liane; Holt, James; van der Veen, Annemarthe G; Giampazolias, Evangelos; Burns, Kathleen H; Maillard, Pierre V; Rowe, Helen M. The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s. Nature Communications. 2020;11(1):5387.