Anti Phospho-ERN1 (S724) mAb (Clone 1F12)

CUSABIO

Catalog No.:
CSB-RA007795A724phHU-50
Western Blot<br /> Positive WB detected in: 293 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate (treated with Calyculin A or EGF)<br /> All lanes: Phospho-ERN1 antibody at 0.75&mu;g/ml<br /> Secondary<br /> Goat polyclonal to rabbit IgG at 1/50000 dilution<br /> Predicted band size: 110 kDa<br /> Observed band size: 110 kDa
Immunofluorescence staining of Hela cells with CSB-RA007795A724phHU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4&deg;C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).

Product Specifications
Application WB, IF, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 1F12)

Documents & Links for Anti Phospho-ERN1 (S724) mAb (Clone 1F12)
Datasheet Anti Phospho-ERN1 (S724) mAb (Clone 1F12) Datasheet

Documents & Links for Anti Phospho-ERN1 (S724) mAb (Clone 1F12)
Datasheet Anti Phospho-ERN1 (S724) mAb (Clone 1F12) Datasheet
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