Anti NR3C1 mAb (Clone 2D8)

CUSABIO

Catalog No.:
CSB-RA958910A0HU-50
Western Blot<br /> Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, U87 whole cell lysate<br /> All lanes: NR3C1 antibody at 1:1500<br /> Secondary<br /> Goat polyclonal to rabbit IgG at 1/50000 dilution<br /> Predicted band size: 86, 83, 82, 77, 76, 65, 61, 52, 51, 50 kDa<br /> Observed band size: 95 kDa<br />
Overlay histogram showing Jurkat cells stained with CSB-RA958910A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*106cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
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Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).

Product Specifications
Application WB, FC, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 2D8)

Documents & Links for Anti NR3C1 mAb (Clone 2D8)
Datasheet Anti NR3C1 mAb (Clone 2D8) Datasheet

Documents & Links for Anti NR3C1 mAb (Clone 2D8)
Datasheet Anti NR3C1 mAb (Clone 2D8) Datasheet
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