Anti NPC1L1 mAb (Clone 4B10)

CUSABIO

Catalog No.:
CSB-RA921474A0HU-50
IHC image of CSB-RA921474A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
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Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.

Product Specifications
Application IHC, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 4B10)

Documents & Links for Anti NPC1L1 mAb (Clone 4B10)
Datasheet Anti NPC1L1 mAb (Clone 4B10) Datasheet

Documents & Links for Anti NPC1L1 mAb (Clone 4B10)
Datasheet Anti NPC1L1 mAb (Clone 4B10) Datasheet
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