Anti Muscarinic acetylcholine receptor M1 (CHRM1) pAb (Rabbit, Antiserum)

Cosmo Bio LTD

Catalog No: CAC-YCU-PS-M1

Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

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Application: IP 
Clonality: Polyclonal 
Host: Rabbit 
Purification: Serum 
Reactivity: Porcine, Human 

Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system. Muscarinic receptors are so named because they are more sensitive to muscarine than to nicotine. By the use of selective radioactively labeled agonist and antagonist substances, five subtypes of muscarinic receptors have been determined, named M1-M5 (using an upper case M and subscript number). M1, M3, M5 receptors are coupled with Gq proteins, while M2 and M4 receptors are coupled with Gi/o proteins.

M1 receptor: This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve[citation needed], is common in exocrine glands and in the CNS. It is predominantly found bound to G proteins of class Gq, which use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signaling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, Gi (causing a downstream decrease in cAMP) and Gs (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX, respectively.

References:
1) K. Shiozaki, E. Iseki, H. Uchiyama, Y. Watanabe, T. Haga, K. Kameyama, T. Yamada, T. Yamamoto, K. Kosaka Alterations of muscarinic acetylcholine receptor subtypes in diffuse Lewy body disease: relation to Alzheimer's's disease J Neurol Neurosurg Psychiatry. 1999 Aug; 67 (2): 209-13.
2) Kazumasa Shiozaki, Eizo Iseki, Hiroaki Hino, Kenji Kosaka Distribution of m1 acetylcholine receptors in the hippocampus of patients with patients and patients with dementia with Lewy bodies-an immunohistochemistry study J Neurol Sci. 2001 Dec 15.