Anti MICU1 pAb (ATL-HPA037480)

Atlas Antibodies

Catalog No.: ATL-HPA037480-25

Protein Description: mitochondrial calcium uptake 1
Gene Name: MICU1
Alternative Gene Name: CALC, CBARA1, EFHA3, FLJ12684
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000020111: 98%, ENSRNOG00000043436: 98%
Entrez Gene ID: 10367
Uniprot ID: Q9BPX6
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: LKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFL
• Gene Sequence: LKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFL
• Gene ID - Mouse: ENSMUSG00000020111
• Gene ID - Rat: ENSRNOG00000043436
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti MICU1 pAb (ATL-HPA037480) – 19 Found

Lee, Youngjin; Min, Choon Kee; Kim, Tae Gyun; Song, Hong Ki; Lim, Yunki; Kim, Dongwook; Shin, Kahee; Kang, Moonkyung; Kang, Jung Youn; Youn, Hyung-Seop; Lee, Jung-Gyu; An, Jun Yop; Park, Kyoung Ryoung; Lim, Jia Jia; Kim, Ji Hun; Kim, Ji Hye; Park, Zee Yong; Kim, Yeon-Soo; Wang, Jimin; Kim, Do Han; Eom, Soo Hyun. Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter. Embo Reports. 2015;16(10):1318-33. 

Vais, Horia; Mallilankaraman, Karthik; Mak, Don-On Daniel; Hoff, Henry; Payne, Riley; Tanis, Jessica E; Foskett, J Kevin. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Reports. 2016;14(3):403-410. 

De La Fuente, Sergio; Fernandez-Sanz, Celia; Vail, Caitlin; Agra, Elorm J; Holmstrom, Kira; Sun, Junhui; Mishra, Jyotsna; Williams, Dewight; Finkel, Toren; Murphy, Elizabeth; Joseph, Suresh K; Sheu, Shey-Shing; Csordás, György. Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle. The Journal Of Biological Chemistry. 2016;291(44):23343-23362. 

Suarez, Jorge; Cividini, Federico; Scott, Brian T; Lehmann, Kim; Diaz-Juarez, Julieta; Diemer, Tanja; Dai, Anzhi; Suarez, Jorge A; Jain, Mohit; Dillmann, Wolfgang H. Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function. The Journal Of Biological Chemistry. 2018;293(21):8182-8195. 

Phillips, Charles B; Tsai, Chen-Wei; Tsai, Ming-Feng. The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex. Elife. 2019;8( 30638448) 

Balderas, Enrique; Eberhardt, David R; Lee, Sandra; Pleinis, John M; Sommakia, Salah; Balynas, Anthony M; Yin, Xue; Parker, Mitchell C; Maguire, Colin T; Cho, Scott; Szulik, Marta W; Bakhtina, Anna; Bia, Ryan D; Friederich, Marisa W; Locke, Timothy M; Van Hove, Johan L K; Drakos, Stavros G; Sancak, Yasemin; Tristani-Firouzi, Martin; Franklin, Sarah; Rodan, Aylin R; Chaudhuri, Dipayan. Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment. Nature Communications. 2022;13(1):2769. 

Logan, Clare V; Szabadkai, György; Sharpe, Jenny A; Parry, David A; Torelli, Silvia; Childs, Anne-Marie; Kriek, Marjolein; Phadke, Rahul; Johnson, Colin A; Roberts, Nicola Y; Bonthron, David T; Pysden, Karen A; Whyte, Tamieka; Munteanu, Iulia; Foley, A Reghan; Wheway, Gabrielle; Szymanska, Katarzyna; Natarajan, Subaashini; Abdelhamed, Zakia A; Morgan, Joanne E; Roper, Helen; Santen, Gijs W E; Niks, Erik H; van der Pol, W Ludo; Lindhout, Dick; Raffaello, Anna; De Stefani, Diego; den Dunnen, Johan T; Sun, Yu; Ginjaar, Ieke; Sewry, Caroline A; Hurles, Matthew; Rizzuto, Rosario; Duchen, Michael R; Muntoni, Francesco; Sheridan, Eamonn. Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nature Genetics. 2014;46(2):188-93. 

Antony, Anil Noronha; Paillard, Melanie; Moffat, Cynthia; Juskeviciute, Egle; Correnti, Jason; Bolon, Brad; Rubin, Emanuel; Csordás, György; Seifert, Erin L; Hoek, Jan B; Hajnóczky, György. MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nature Communications. 2016;7( 26956930):10955. 

Naon, Deborah; Zaninello, Marta; Giacomello, Marta; Varanita, Tatiana; Grespi, Francesca; Lakshminaranayan, Sowmya; Serafini, Annalisa; Semenzato, Martina; Herkenne, Stephanie; Hernández-Alvarez, Maria Isabel; Zorzano, Antonio; De Stefani, Diego; Dorn, Gerald W 2nd; Scorrano, Luca. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2016;113(40):11249-11254. 

Kamer, Kimberli J; Grabarek, Zenon; Mootha, Vamsi K. High-affinity cooperative Ca(2+) binding by MICU1-MICU2 serves as an on-off switch for the uniporter. Embo Reports. 2017;18(8):1397-1411. 

Kamer, Kimberli J; Sancak, Yasemin; Fomina, Yevgenia; Meisel, Joshua D; Chaudhuri, Dipayan; Grabarek, Zenon; Mootha, Vamsi K. MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca(2+) and Mn(2+). Proceedings Of The National Academy Of Sciences Of The United States Of America. 2018;115(34):E7960-E7969. 

Marchi, Saverio; Corricelli, Mariangela; Branchini, Alessio; Vitto, Veronica Angela Maria; Missiroli, Sonia; Morciano, Giampaolo; Perrone, Mariasole; Ferrarese, Mattia; Giorgi, Carlotta; Pinotti, Mirko; Galluzzi, Lorenzo; Kroemer, Guido; Pinton, Paolo. Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca(2+) levels and tumor growth. The Embo Journal. 2019;38(2) 

Marchi, Saverio; Vitto, Veronica Angela Maria; Patergnani, Simone; Pinton, Paolo. High mitochondrial Ca(2+) content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP). Cell Cycle (Georgetown, Tex.). 2019;18(8):914-916. 

Liu, Julia C; Syder, Nicole C; Ghorashi, Nima S; Willingham, Thomas B; Parks, Randi J; Sun, Junhui; Fergusson, Maria M; Liu, Jie; Holmström, Kira M; Menazza, Sara; Springer, Danielle A; Liu, Chengyu; Glancy, Brian; Finkel, Toren; Murphy, Elizabeth. EMRE is essential for mitochondrial calcium uniporter activity in a mouse model. Jci Insight. 2020;5(4) 

Calvo-Rodriguez, Maria; Hou, Steven S; Snyder, Austin C; Kharitonova, Elizabeth K; Russ, Alyssa N; Das, Sudeshna; Fan, Zhanyun; Muzikansky, Alona; Garcia-Alloza, Monica; Serrano-Pozo, Alberto; Hudry, Eloise; Bacskai, Brian J. Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease. Nature Communications. 2020;11(1):2146. 

Dia, Maya; Gomez, Ludovic; Thibault, Helene; Tessier, Nolwenn; Leon, Christelle; Chouabe, Christophe; Ducreux, Sylvie; Gallo-Bona, Noelle; Tubbs, Emily; Bendridi, Nadia; Chanon, Stephanie; Leray, Aymeric; Belmudes, Lucid; Couté, Yohann; Kurdi, Mazen; Ovize, Michel; Rieusset, Jennifer; Paillard, Melanie. Reduced reticulum-mitochondria Ca(2+) transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy. Basic Research In Cardiology. 2020;115(6):74. 

Quezada, Esteban R; Díaz-Vegas, Alexis; Jaimovich, Enrique; Casas, Mariana. Changes in Gene Expression of the MCU Complex Are Induced by Electrical Stimulation in Adult Skeletal Muscle. Frontiers In Physiology. 11( 33574764):601313. 

Katona, Máté; Bartók, Ádám; Nichtova, Zuzana; Csordás, György; Berezhnaya, Elena; Weaver, David; Ghosh, Arijita; Várnai, Péter; Yule, David I; Hajnóczky, György. Capture at the ER-mitochondrial contacts licenses IP(3) receptors to stimulate local Ca(2+) transfer and oxidative metabolism. Nature Communications. 2022;13(1):6779. 

Mira, Rodrigo G; Quintanilla, Rodrigo A; Cerpa, Waldo. Mild Traumatic Brain Injury Induces Mitochondrial Calcium Overload and Triggers the Upregulation of NCLX in the Hippocampus. Antioxidants (Basel, Switzerland). 2023;12(2)