Anti METAP2 mAb (Clone 8F2)

CUSABIO

SKU: CSB-RA294332A0HU-50

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Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.

Product Specifications

• Application: IHC, ELISA
• Reactivity: Human
• Clonality: Monoclonal (Clone No.: 8F2)