Anti LGR5 mAb (Clone 4H8)

CUSABIO

Catalog No.:
CSB-RA262034A0HU-50
Western Blot<br /> Positive WB detected in: SH-SY5Y whole cell lysate, Rat brain tissue<br /> All lanes: LGR5 antibody at 1:1500<br /> Secondary<br /> Goat polyclonal to rabbit IgG at 1/50000 dilution<br /> Predicted band size: 100, 98, 93 kDa<br /> Observed band size: 100 kDa<br />
Overlay histogram showing HepG2 cells stained with CSB-RA262034A0HU (red line) at 1:50. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*106cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
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Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Product Specifications
Application WB, FC, ELISA
Reactivity Human, Rat
Clonality Monoclonal (Clone No.: 4H8)

Documents & Links for Anti LGR5 mAb (Clone 4H8)
Datasheet Anti LGR5 mAb (Clone 4H8) Datasheet

Documents & Links for Anti LGR5 mAb (Clone 4H8)
Datasheet Anti LGR5 mAb (Clone 4H8) Datasheet
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