Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.
Click here to browse a well organized list of products for Bone, Collagen, and Extracellular Matrix research.
Application: IP, IF, WB, IHC(f)Clonality: Monoclonal
Host: Mouse
Purification: Supernatant
Reactivity: Rabbit, Bovine, Human
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituents of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are heterotrimers composed of 3 non-identical chains that adopt a cruciform structure with 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene and in some cases undergoes alternative splicing to give rise to separate chain variants.
References:
1) Hirako Y., Yoshino K., Zillikens D., Owaribe K. Extracellular cleavage of bullous pemphigoid antigen 180/type XVII collagen and its involvement in hemidesmosomal disassembly. J Biochem. 2003 Feb;133(2):197-206. PMID: 12761182
2) Uematsu J., Nishizawa Y., Hirako Y., Kitamura K., Usukura J., Miyata T., Owaribe K. Both type-I hemidesmosomes and adherens-type junctions contribute to the cell-substratum adhesion system in myoepithelial cells. Eur J Cell Biol. 2005 Mar;84(2-3):407-15. PMID: 15819417
3) Owaribe K, Nishizawa Y, Franke WW. Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells. Exp Cell Res. 1991 Feb;192(2):622-30. PMID:1988297
| Documents & Links for Anti Laminin Subunit Alpha-3 mAb (Clone BM515) | |
| Datasheet | cac-nu-01-la3_anti-laminin-alpha3-mab-clone-bm515_datasheet.pdf |
| Documents & Links for Anti Laminin Subunit Alpha-3 mAb (Clone BM515) | |
| Datasheet | cac-nu-01-la3_anti-laminin-alpha3-mab-clone-bm515_datasheet.pdf |
| Citations for Anti Laminin Subunit Alpha-3 mAb (Clone BM515) – 2 Found |
| Kamaguchi et al. 2019. The identification of autoantigens in mucous membrane pemphigoid using immortalized oral mucosal keratinocytes. J Oral Path Med. 48(1):60-67. Journal |
| Yamane et al. 2016. Engineered three-dimensional rabbit oral epithelial–mesenchymal–muscular hybrid sheets. Int J Oral Sci. 8(3):145-54. PubMed, Journal |