Anti L-Type Amino Acid Transporter 1 / LAT1 pAb

Cosmo Bio

SKU: KAL-KE026

Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection of amino acid molecule variety, and is classfied into various transport systems by the transportative substrate selectivity and the Na+ dependence with the reflection of amino acid molecule variety. L-type amino acid transporter 1 (LAT1) is a predicted 12 membrane-spanning protein and is unique because it requires an additional single membrane spanning protein, 4F2 heavy chain (4F2hc:CD98), for its functional expression. L-type is Na+ -independent neutral amino acid transporter agency and essential for the transporter of large neutral amino acid such as Leucine, Isoleucine, Varine through the plasma membrane. LAT1 is, thus transporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-related drugs such as L-DOPA. LAT has been proposed to be one of the major nutrient transport systems at the blood-brain barrier. Highly regulated nature and high level of expression in tumor cell lines, LAT is thought to be up-regulated to support the high protein synthesis for cell glowth and cell activation. This antibody has been proved to be useful for the immunohistochemistry

Product Specifications

• Application: IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit

Citations for Anti L-Type Amino Acid Transporter 1 / LAT1 pAb – 3 Found

Chen, Rui; Zou, Yilong; Mao, Dongxue; Sun, Daxiao; Gao, Guanguang; Shi, Jingwen; Liu, Xiaoqing; Zhu, Chen; Yang, Mingyu; Ye, Wanlu; Hao, Qianqian; Li, Ruiqiang; Yu, Li. The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation. The Journal Of Cell Biology. 2014;206(2):173-82. 

Wittig, Andrea; Sheu-Grabellus, Sien-Yi; Collette, Laurence; Moss, Raymond; Brualla, Lorenzo; Sauerwein, Wolfgang. BPA uptake does not correlate with LAT1 and Ki67 expressions in tumor samples (results of EORTC trial 11001). Applied Radiation And Isotopes : Including Data, Instrumentation And Methods For Use In Agriculture, Industry And Medicine. 2011;69(12):1807-12. 

Wang, Qian; Bailey, Charles G; Ng, Cynthia; Tiffen, Jessamy; Thoeng, Annora; Minhas, Vineet; Lehman, Melanie L; Hendy, Stephen C; Buchanan, Grant; Nelson, Colleen C; Rasko, John E J; Holst, Jeff. Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Cancer Research. 2011;71(24):7525-36.