Anti KMT2D pAb (ATL-HPA035977)

Atlas Antibodies

Catalog No.: ATL-HPA035977-25

Protein Description: lysine (K)-specific methyltransferase 2D
Gene Name: KMT2D
Alternative Gene Name: ALR, CAGL114, MLL2, MLL4, TNRC21
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000048154: 90%, ENSRNOG00000061499: 84%
Entrez Gene ID: 8085
Uniprot ID: O14686
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: ICC, IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: AQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHI
• Gene Sequence: AQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAEINGHI
• Gene ID - Mouse: ENSMUSG00000048154
• Gene ID - Rat: ENSRNOG00000061499
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti KMT2D pAb (ATL-HPA035977) – 10 Found

Lin-Shiao, Enrique; Lan, Yemin; Coradin, Mariel; Anderson, Amy; Donahue, Greg; Simpson, Cory L; Sen, Payel; Saffie, Rizwan; Busino, Luca; Garcia, Benjamin A; Berger, Shelley L; Capell, Brian C. KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis. Genes & Development. 2018;32(2):181-193. 

Toska, Eneda; Castel, Pau; Chhangawala, Sagar; Arruabarrena-Aristorena, Amaia; Chan, Carmen; Hristidis, Vasilis C; Cocco, Emiliano; Sallaku, Mirna; Xu, Guotai; Park, Jane; Minuesa, Gerard; Shifman, Sophie G; Socci, Nicholas D; Koche, Richard; Leslie, Christina S; Scaltriti, Maurizio; Baselga, José. PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression. Cell Reports. 2019;27(1):294-306.e5. 

Zheng, Biqiang; Song, Zhijian; Chen, Yong; Yan, Wangjun. Genomic Analyses of Metaplastic or Sarcomatoid Carcinomas From Different Organs Revealed Frequent Mutations in KMT2D. Frontiers In Molecular Biosciences. 8( 34336928):688692. 

Egolf, Shaun; Zou, Jonathan; Anderson, Amy; Simpson, Cory L; Aubert, Yann; Prouty, Stephen; Ge, Kai; Seykora, John T; Capell, Brian C. MLL4 mediates differentiation and tumor suppression through ferroptosis. Science Advances. 2021;7(50):eabj9141. 

Dubuc, Adrian M; Remke, Marc; Korshunov, Andrey; Northcott, Paul A; Zhan, Shing H; Mendez-Lago, Maria; Kool, Marcel; Jones, David T W; Unterberger, Alexander; Morrissy, A Sorana; Shih, David; Peacock, John; Ramaswamy, Vijay; Rolider, Adi; Wang, Xin; Witt, Hendrik; Hielscher, Thomas; Hawkins, Cynthia; Vibhakar, Rajeev; Croul, Sidney; Rutka, James T; Weiss, William A; Jones, Steven J M; Eberhart, Charles G; Marra, Marco A; Pfister, Stefan M; Taylor, Michael D. Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathologica. 2013;125(3):373-84. 

Zhang, Jiyuan; Dominguez-Sola, David; Hussein, Shafinaz; Lee, Ji-Eun; Holmes, Antony B; Bansal, Mukesh; Vlasevska, Sofija; Mo, Tongwei; Tang, Hongyan; Basso, Katia; Ge, Kai; Dalla-Favera, Riccardo; Pasqualucci, Laura. Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis. Nature Medicine. 2015;21(10):1190-8. 

Hillman, R Tyler; Celestino, Joseph; Terranova, Christopher; Beird, Hannah C; Gumbs, Curtis; Little, Latasha; Nguyen, Tri; Thornton, Rebecca; Tippen, Samantha; Zhang, Jianhua; Lu, Karen H; Gershenson, David M; Rai, Kunal; Broaddus, Russell R; Futreal, P Andrew. KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary. Nature Communications. 2018;9(1):2496. 

Numakura, Satoe; Uozaki, Hiroshi. Low MLL2 Protein Expression Is Associated With Fibrosis in Early Stage Gastric Cancer. In Vivo (Athens, Greece). 2021;35(1):603-609. 

Castro-Piedras, Isabel; Sharma, Monica; Brelsfoard, Jennifer; Vartak, David; Martinez, Edgar G; Rivera, Cristian; Molehin, Deborah; Bright, Robert K; Fokar, Mohamed; Guindon, Josee; Pruitt, Kevin. Nuclear Dishevelled targets gene regulatory regions and promotes tumor growth. Embo Reports. 2021;22(6):e50600. 

Zhai, Qiliang; Luo, Mayao; Zhang, Yifan; Zhang, Wenqiang; Wu, Chenwei; Lv, Shidong; Wei, Qiang. Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer. Translational Cancer Research. 2022;11(8):2607-2621.