Anti ITGA4 mAb (Clone 1H4)

CUSABIO

SKU:
CSB-RA225859A0HU-50
  • Western Blot<br />
Positive WB detected in: Jurkat whole cell lysate<br />
All lanes: ITGA4 antibody at 1:1500<br />
Secondary<br />
Goat polyclonal to rabbit IgG at 1/50000 dilution<br />
Predicted band size: 115, 26 kDa<br />
Observed band size: 140 kDa<br />
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$221.00
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Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).

Product Specifications
Application WB, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 1H4)


Documents & Links for Anti ITGA4 mAb (Clone 1H4)
Datasheet Anti ITGA4 mAb (Clone 1H4) Datasheet

Documents & Links for Anti ITGA4 mAb (Clone 1H4)
Datasheet Anti ITGA4 mAb (Clone 1H4) Datasheet