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Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.
Application: ICC, WB, ELISAClonality: Monoclonal
Host: Rat
Purification: Ion-exchange Chromatography
Reactivity: Hamster, Monkey, Mouse, Rat, Human
Background
Post-translation modifications of histones modulate the accessibility and transcriptional competence of specific chromatin regions within the eukaryotic genome. Phosphorylation of histone H3 Threonine 11 (H3-T11ph) occurs throughout the cell cycle and is Chk1 dependent. It has been reported that DNA damage rapidly reduces H3-T11 phosphorylation.
Application
ã» Western blotting: 1/500
ã» Immunocytochemistry: 1/500
Other applications have not been tested.
Optimal dilutions/concentrations should be determined by the end user.
The composition of Histone H3 peptides and the reactivity of Histone H3 T11ph antibody, 6G12C5.
H3 1 ARTKQTARK S T GGKAPRKQC 19
H3 K9ac 1 ARTKQTARKac S T GGKAPRKQC 19
H3 S10ph 1 ARTKQTARK Sph T GGKAPRKQC 19
H3 T11ph 1 ARTKQTARK S TphGGKAPRKQC 19
H3 K9acT11ph 1 ARTKQTARKac S TphGGKAPRKQC 19
H3 S10phT11ph 1 ARTKQTARK Sph TphGGKAPRKQC 19
H3.1 T32ph 21 ATKAARKSAPA TphGGVKKPH 39
H3.3 T32ph 21 ATKAARKSAPS TphGGVKKPH 39
References
Shimada M, et al. (2008) Cell. 132(2):221-32. PMID: 18243098.
| Documents & Links for Anti Histone H3.1 (HIST1H3A) T11ph mAb (Clone 6G12C5) | |
| Datasheet | Anti Histone H3.1 (HIST1H3A) T11ph mAb (Clone 6G12C5) Datasheet |
| Documents & Links for Anti Histone H3.1 (HIST1H3A) T11ph mAb (Clone 6G12C5) | |
| Datasheet | Anti Histone H3.1 (HIST1H3A) T11ph mAb (Clone 6G12C5) Datasheet |
