Recombinant Human Anti HSV Type 1 + Type 2 Glycoprotein B (HSV-gB) mAb 7-10C; Neutralizing; hPBL-derived

EVEC

Catalog No.: EVC-EVHM0301-50

Background Information

Herpes Simplex Virus (HSV) is a ubiquitous human alpha-herpesvirus that establishes life-long latent infections in human following the primary infection. There are two types of HSV, HSV-1 and HSV-2. The sero-prevalence of HSV-1 is more common than HSV-2. HSV-1 infection commonly develops herpes labialis (cold sore or fever bilsters) and can also cause genital herpes. HSV-2 generally infects genital area and can cause genital herpes. It has been shown that four of HSV-encoded glycoproteins are necessary and sufficient to facilitate membrane fusion between viral and host membranes. Glycoprotein B (gB) mediates membrane fusion in cooperation with glycoprotein H/glycoprotein L complex. HSV-1 and HSV-2 gB exist as a homodimer.

Immunogen and Recombinant Production Host

This antibody was generated from a healthy individual by a method based on the Epstein-Barr virus transformation of peripheral blood mononuclear cells followed by the isolation of antibody-producing cells. The antibody reactivity for the target antigen was screened by immunofluorescent staining by using CHO-K1 cells displaying recombinant HSV gB. The antibody genes were cloned from the antibody-producing cells and introduced into CHO-K1 cells for antibody production.

Product Specifications

• Application: Neutralization, ELISA
• Reactivity: Human
• Clonality: Monoclonal (Clone No.: 7-10C)
• Host: Human