Anti EPAS1 mAb (Clone 6A9)

CUSABIO

SKU:
CSB-RA904931A0HU-50
  • Immunofluorescence staining of Hela Cells with CSB-RA904931A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
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Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Product Specifications
Application IF, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 6A9)


Documents & Links for Anti EPAS1 mAb (Clone 6A9)
Datasheet Anti EPAS1 mAb (Clone 6A9) Datasheet

Documents & Links for Anti EPAS1 mAb (Clone 6A9)
Datasheet Anti EPAS1 mAb (Clone 6A9) Datasheet



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