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Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.
Application: ChIP, ICC, WB, ELISAClonality: Monoclonal
Host: Rat
Purification: Ion-exchange Chromatography, Gel Filtration
Reactivity: Monkey, Mouse, Rat, Human, Hamster
Background
RNA polymerase II (RNAPII) transcribes all protein-coding genes and many non-coding genes, and the activity of RNAPII correlates with the phosphorylation state of RPB1, the large catalytic subunit of RNAPII.. RPB1 has an unusual C-terminal domain (CTD) that consists of repeats of the heptapeptide consensus sequence N-Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7-C, of which there are 52 copies in mammals. The amino acids in these repeats are potential targets for modification, such as phosphorylation and glycosylation.
| Antigen/Source | RNA polymerase 2, CTD Ser2ph |
| Host | Rat |
| Immunogen | Human |
| Reacts with | Human/Mouse/Rat/Monkey/Hamster |
| Clone | 3E7C7 |
| Isotype | IgG2a |
| Conjugation | Unlabeled |
| Fraction | Ig fraction - Ion Exchange /Gel Filtration |
| Applications | Western Blot/Immunocytochemistry (cell)/Chromatin Immunoprecipitation |
| Preservative | 0.05% NaN3 in LIQ |
| Storage | -70C |
References
1) Odawara et al. (2011) BMC Genomics. 12:516. PMID: 22011111.
| Documents & Links for Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser2 mAb (Clone 3E7C7) | |
| Datasheet | Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser2 mAb (Clone 3E7C7) Datasheet |
| Documents & Links for Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser2 mAb (Clone 3E7C7) | |
| Datasheet | Anti DNA-Directed RNA Polymerase II Subunit RPB1 (POLR2A) CTD Phosopho-Ser2 mAb (Clone 3E7C7) Datasheet |
