Anti CMTM6 pAb (ATL-HPA026980)

Atlas Antibodies

Catalog No.: ATL-HPA026980-25

Protein Description: CKLF-like MARVEL transmembrane domain containing 6
Gene Name: CMTM6
Alternative Gene Name: CKLFSF6, FLJ20396
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000032434: 72%, ENSRNOG00000010951: 80%
Entrez Gene ID: 54918
Uniprot ID: Q9NX76
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: WB, ICC, IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: KRQESQLRKPENTTRAEALTEPLNA
• Gene Sequence: KRQESQLRKPENTTRAEALTEPLNA
• Gene ID - Mouse: ENSMUSG00000032434
• Gene ID - Rat: ENSRNOG00000010951
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti CMTM6 pAb (ATL-HPA026980) – 14 Found

Mezzadra, Riccardo; Sun, Chong; Jae, Lucas T; Gomez-Eerland, Raquel; de Vries, Evert; Wu, Wei; Logtenberg, Meike E W; Slagter, Maarten; Rozeman, Elisa A; Hofland, Ingrid; Broeks, Annegien; Horlings, Hugo M; Wessels, Lodewyk F A; Blank, Christian U; Xiao, Yanling; Heck, Albert J R; Borst, Jannie; Brummelkamp, Thijn R; Schumacher, Ton N M. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature. 2017;549(7670):106-110. 

Burr, Marian L; Sparbier, Christina E; Chan, Yih-Chih; Williamson, James C; Woods, Katherine; Beavis, Paul A; Lam, Enid Y N; Henderson, Melissa A; Bell, Charles C; Stolzenburg, Sabine; Gilan, Omer; Bloor, Stuart; Noori, Tahereh; Morgens, David W; Bassik, Michael C; Neeson, Paul J; Behren, Andreas; Darcy, Phillip K; Dawson, Sarah-Jane; Voskoboinik, Ilia; Trapani, Joseph A; Cebon, Jonathan; Lehner, Paul J; Dawson, Mark A. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature. 2017;549(7670):101-105. 

Muranushi, Ryo; Araki, Kenichiro; Yokobori, Takehiko; Chingunjav, Batbayar; Hoshino, Kouki; Dolgormaa, Gantumur; Hagiwara, Kei; Yamanaka, Takahiro; Ishii, Norihiro; Tsukagoshi, Mariko; Igarashi, Takamichi; Watanabe, Akira; Kubo, Norio; Harimoto, Norifumi; Shimoda, Yuki; Sano, Rie; Oyama, Tetsunari; Saeki, Hiroshi; Shirabe, Ken. High membrane expression of CMTM6 in hepatocellular carcinoma is associated with tumor recurrence. Cancer Science. 2021;112(8):3314-3323. 

Wang, Ziqi; Peng, Zhi; Liu, Qiyao; Guo, Zixia; Menatola, Merey; Su, Jing; Li, Ting; Ge, Qing; Wang, Pingzhang; Shen, Lin; Jin, Rong. Co-Expression with Membrane CMTM6/4 on Tumor Epithelium Enhances the Prediction Value of PD-L1 on Anti-PD-1/L1 Therapeutic Efficacy in Gastric Adenocarcinoma. Cancers. 2021;13(20) 

Wang, Hanfeng; Fan, Yang; Chen, Weihao; Lv, Zheng; Wu, Shengpan; Xuan, Yundong; Wang, Chenfeng; Lu, Yongliang; Guo, Tao; Shen, Donglai; Zhang, Fan; Huang, Qingbo; Gao, Yu; Li, Hongzhao; Ma, Xin; Wang, Baojun; Huang, Yan; Zhang, Xu. Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity. Oncoimmunology. 11(1):2011673. 

Takeuchi, Hiroto; Konnai, Satoru; Maekawa, Naoya; Minato, Erina; Ichikawa, Yoshiki; Kobayashi, Atsushi; Okagawa, Tomohiro; Murata, Shiro; Ohashi, Kazuhiko. Expression Analysis of Canine CMTM6 and CMTM4 as Potential Regulators of the PD-L1 Protein in Canine Cancers. Frontiers In Veterinary Science. 7( 32596272):330. 

Zheng, Yang; Wang, Chundi; Song, An; Jiang, Feng; Zhou, Junbo; Li, Gang; Zhang, Wei; Ye, Jinhai; Ding, Xu; Zhang, Wei; Du, Yifei; Zhang, Hongchuang; Wu, Heming; Song, Xiaomeng; Wu, Yunong. CMTM6 promotes cell proliferation and invasion in oral squamous cell carcinoma by interacting with NRP1. American Journal Of Cancer Research. 10(6):1691-1709. 

Mohapatra, Pallavi; Shriwas, Omprakash; Mohanty, Sibasish; Ghosh, Arup; Smita, Shuchi; Kaushik, Sandeep Rai; Arya, Rakesh; Rath, Rachna; Das Majumdar, Saroj Kumar; Muduly, Dillip Kumar; Raghav, Sunil K; Nanda, Ranjan K; Dash, Rupesh. CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis. Jci Insight. 2021;6(4) 

Yugawa, Kyohei; Itoh, Shinji; Yoshizumi, Tomoharu; Iseda, Norifumi; Tomiyama, Takahiro; Morinaga, Akinari; Toshima, Takeo; Harada, Noboru; Kohashi, Kenichi; Oda, Yoshinao; Mori, Masaki. CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma. Hepatology Communications. 2021;5(2):334-348. 

Peng, Qi-Hua; Wang, Chun-Hua; Chen, Hong-Min; Zhang, Rong-Xin; Pan, Zhi-Zhong; Lu, Zhen-Hai; Wang, Gao-Yuan; Yue, Xin; Huang, Wenlin; Liu, Ran-Yi. CMTM6 and PD-L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer. Journal For Immunotherapy Of Cancer. 2021;9(2) 

Xiao, Malina; Hasmim, Meriem; Lequeux, Audrey; Moer, Kris Van; Tan, Tuan Zea; Gilles, Christine; Hollier, Brett G; Thiery, Jean Paul; Berchem, Guy; Janji, Bassam; Noman, Muhammad Zaeem. Epithelial to Mesenchymal Transition Regulates Surface PD-L1 via CMTM6 and CMTM7 Induction in Breast Cancer. Cancers. 2021;13(5) 

Chen, Li-Mei; Chai, Julius C; Liu, Bin; Strutt, Tara M; McKinstry, K Kai; Chai, Karl X. Prostasin regulates PD-L1 expression in human lung cancer cells. Bioscience Reports. 2021;41(7) 

Tang, Tianyu; Huang, Xing; Zhang, Gang; Lu, Minghao; Hong, Zhengtao; Wang, Meng; Huang, Junming; Zhi, Xiao; Liang, Tingbo. Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis. Journal For Immunotherapy Of Cancer. 2022;10(3) 

Xing, Fei; Gao, Hongli; Chen, Guanglei; Sun, Lisha; Sun, Jiayi; Qiao, Xinbo; Xue, Jinqi; Liu, Caigang. CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer. Molecular Cancer. 2023;22(1):6.