Application: WB, IHC, IF, ELISA
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human, Mouse
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Clonality: Monoclonal
Purification: Purified - Affinity
Reactivity: Human, Mouse
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
| Documents & Links for Anti CDKN1B mAb (Clone 1G2) | |
| Datasheet | Anti CDKN1B mAb (Clone 1G2) Datasheet |
| Vendor Page | Anti CDKN1B mAb (Clone 1G2) at CUSABIO |
| Documents & Links for Anti CDKN1B mAb (Clone 1G2) | |
| Datasheet | Anti CDKN1B mAb (Clone 1G2) Datasheet |
| Vendor Page | Anti CDKN1B mAb (Clone 1G2) |
![Characterization of neurocan peptide pAb and neurocan mAb (clone 1G2) with samples obtained from 10-day-old rat brain. PBS-soluble brain CSPG mixture of 10-day-old rats (lane 1) and brain PBS-extract digested with chondroitinase ABC (lanes 2 and 3) were separated by SDS-PAGE. Neurocan peptide pAb recognized a very diffuse band with the same mobility as that recognized by neurocan mAb (clone 1G2). Monoclonal antibody (clone 1G2) recognized both 240 and 150 kDa core glycoproteins in the chondroitinase-digested sample. The polyclonal antibody recognized not only the 240 kDa core glycoprotein but also one with a molecular weight of 130 kDa. [from: Neurochem. Int. (1994) 25:425-431.]](https://cdn11.bigcommerce.com/s-ydswqc5qsc/images/stencil/500x659/products/29732/120198/cac-nu-07-002_anti-neurocan-mab-clone-1g2_1306__20473.1620917124.png?c=2 "Characterization of neurocan peptide pAb and neurocan mAb (clone 1G2) with samples obtained from 10-day-old rat brain. PBS-soluble brain CSPG mixture of 10-day-old rats (lane 1) and brain PBS-extract digested with chondroitinase ABC (lanes 2 and 3) were separated by SDS-PAGE. Neurocan peptide pAb recognized a very diffuse band with the same mobility as that recognized by neurocan mAb (clone 1G2). Monoclonal antibody (clone 1G2) recognized both 240 and 150 kDa core glycoproteins in the chondroitinase-digested sample. The polyclonal antibody recognized not only the 240 kDa core glycoprotein but also one with a molecular weight of 130 kDa. [from: Neurochem. Int. (1994) 25:425-431.]")
