Anti CDC42 mAb (Clone 3C3)

CUSABIO

SKU: CSB-RA177985A0HU-50

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Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity).

Product Specifications

• Application: WB, IHC, ELISA
• Reactivity: Human, Mouse
• Clonality: Monoclonal (Clone No.: 3C3)