Anti-CD8 (Mouse) mAb-PE (Clone: KT15)

MBL Life Sciences

SKU: MBL-K0227-5

he CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two α chains, or a heterodimer composed of one α and one β chain. Both α and β chains share significant homology to immunoglobulin variable light chains. CD8 α chains binds to class-I MHC molecules α3 domains. CD8 identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. This monoclonal antibody KT15 reacts with a non-polymorphic epitope on the mouse CD8 α chain (mouse Ly2.1 and Ly2.2 cells). This monoclonal antibody KT15 reacts with a non-polymorphic epitope on the mouse CD8 α chain (mouse Ly2.1 and Ly2.2 cells)

Product Specifications

• Application: FC
• Reactivity: Mouse
• Clonality: Monoclonal IgG2a λ
• Host: Rat
• Immunogen: T cell clone C6, H-2K^k restricted H-Y antigen specific CTL
• Gene ID - Mouse:

  12525

• Formulation: 100 tests in 1 mL volume of PBS containing 1% BSA and 0.09% NaN3.