Anti BCL2 mAb (Clone 3F6)

CUSABIO

SKU: CSB-RA564360A0HU-50

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Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

Product Specifications

• Application: WB, IHC, ELISA
• Reactivity: Human, Mouse
• Clonality: Monoclonal (Clone No.: 3F6)