Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.
Application: WB, IHC, IPClonality: Polyclonal
Host: Rabbit
Purification: Serum
Reactivity: Human, Mouse
Component of the Set-2/Ash-2 histone methyltransferase (HMT) complex. Required for di- and trimethylation at Lys-4 of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as a transcriptional regulator. Acts in the germline to limit soma longevity, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids.
References:
Koide et al. The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: Possible role for placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2. J. Biochem. 134. 433-440.
| Documents & Links for Anti Achaete-Scute Homolog 2 (ASH-2/MASH-2) pAb (Rabbit, Antiserum) | |
| Datasheet | cac-sk-t01-004_anti-ash-2-pab_datasheet.pdf |
| Documents & Links for Anti Achaete-Scute Homolog 2 (ASH-2/MASH-2) pAb (Rabbit, Antiserum) | |
| Datasheet | cac-sk-t01-004_anti-ash-2-pab_datasheet.pdf |