Anti ARPC1A pAb (ATL-HPA004334 w/enhanced validation)

Atlas Antibodies

SKU: ATL-HPA004334-25

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Protein Description: actin related protein 2/3 complex subunit 1A
Gene Name: ARPC1A
Alternative Gene Name: Arc40, SOP2Hs, SOP2L
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000029621: 98%, ENSRNOG00000000996: 84%
Entrez Gene ID: 10552
Uniprot ID: Q92747
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: WB, ICC, IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: HGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGI
• Gene Sequence: HGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGI
• Gene ID - Mouse: ENSMUSG00000029621
• Gene ID - Rat: ENSRNOG00000000996
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti ARPC1A pAb (ATL-HPA004334 w/enhanced validation) – 7 Found

Kahr, Walter H A; Pluthero, Fred G; Elkadri, Abdul; Warner, Neil; Drobac, Marko; Chen, Chang Hua; Lo, Richard W; Li, Ling; Li, Ren; Li, Qi; Thoeni, Cornelia; Pan, Jie; Leung, Gabriella; Lara-Corrales, Irene; Murchie, Ryan; Cutz, Ernest; Laxer, Ronald M; Upton, Julia; Roifman, Chaim M; Yeung, Rae S M; Brumell, John H; Muise, Aleixo M. Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease. Nature Communications. 2017;8( 28368018):14816. 

Galloni, Chiara; Carra, Davide; Abella, Jasmine V G; Kjær, Svend; Singaravelu, Pavithra; Barry, David J; Kogata, Naoko; Guérin, Christophe; Blanchoin, Laurent; Way, Michael. MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes. The Journal Of Cell Biology. 2021;220(8) 

Leung, Gabriella; Zhou, Yuhuan; Ostrowski, Philip; Mylvaganam, Sivakami; Boroumand, Parastoo; Mulder, Daniel J; Guo, Conghui; Muise, Aleixo M; Freeman, Spencer A. ARPC1B binds WASP to control actin polymerization and curtail tonic signaling in B cells. Jci Insight. 2021;6(23) 

Molinie, Nicolas; Rubtsova, Svetlana N; Fokin, Artem; Visweshwaran, Sai P; Rocques, Nathalie; Polesskaya, Anna; Schnitzler, Anne; Vacher, Sophie; Denisov, Evgeny V; Tashireva, Lubov A; Perelmuter, Vladimir M; Cherdyntseva, Nadezhda V; Bièche, Ivan; Gautreau, Alexis M. Cortical branched actin determines cell cycle progression. Cell Research. 2019;29(6):432-445. 

Mohan, Ashwathi S; Dean, Kevin M; Isogai, Tadamoto; Kasitinon, Stacy Y; Murali, Vasanth S; Roudot, Philippe; Groisman, Alex; Reed, Dana K; Welf, Erik S; Han, Sangyoon J; Noh, Jungsik; Danuser, Gaudenz. Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1(P29S) Melanoma Cells. Developmental Cell. 2019;49(3):444-460.e9. 

Randzavola, Lyra O; Strege, Katharina; Juzans, Marie; Asano, Yukako; Stinchcombe, Jane C; Gawden-Bone, Christian M; Seaman, Matthew Nj; Kuijpers, Taco W; Griffiths, Gillian M. Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. The Journal Of Clinical Investigation. 2019;129(12):5600-5614. 

von Loeffelholz, Ottilie; Purkiss, Andrew; Cao, Luyan; Kjaer, Svend; Kogata, Naoko; Romet-Lemonne, Guillaume; Way, Michael; Moores, Carolyn A. Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms. Biology Open. 2020;9(7)