Are you familiar with Atelocollagen Powder?
When a high-concentration atelocollagen solution is needed for applications such as scaffold preparation, coating, cell transplantation, or the sustained release of bioactive substances, you can easily prepare a solution at a concentration suited to your research using Atelocollagen Powder.
The team at Koken, a leading Japanese innovator in collagen-based biomaterials, has seen atelocollagen used in combination with more than 20 different substances, reflecting its excellent biocompatibility and long-standing application in medical devices. In this blog, we would like to introduce you to 10 selected papers that have utilized Atelocollagen Powder with great success.
Ten Examples of Successful Atelocollagen Combinations
| Substance Combined with Atelocollagen | Application | Paper Information |
Alginate | Fibroblast-containing beads were prepared, and melanoma cells were cultured with the beads. | Multi-layered cell assembling technology using dielectrophoresis and construction of skin tissue microelement. Yu SUGIMOTO, Shogo MIYATA. Transactions of the JSME (in Japanese) Vol. 83 (2017) No. 848 p. 16-00387. |
| Chitosan + β-Glycerophosphate + Nano-hydroxyapatite + Calcium Carbonate | A scaffold was prepared, and osteoblasts were cultured. | Effects of Calcium Carbonate Microcapsules and Nanohydroxyapatite on Properties of Thermosensitive Chitosan/Collagen Hydrogels. Arpornmaeklong P, Jaiman N, Apinyauppatham K, Fuongfuchat A, Boonyuen S. Polymers (Basel). 2023 Jan 12;15(2):416. PMID: 36679297. |
| Coumaric Acid + rhCOMP-Ang1 | A scaffold was prepared and transplanted into a mandibular bone defect model. | Functional improvement of collagen-based bioscaffold to enhance periodontal-defect healing via combination with dietary antioxidant and COMP-angiopoietin 1. Bhattarai G, Jeon YM, Choi KC, Wagle S, Sim HJ, Kim JI, Zhao S, Kim JG, Cho ES, Kook SH, Lee JC. Mater Sci Eng C Mater Biol Appl. 2022 Apr;135:112673. PMID: 35581065. |
| Silk + Hyaluronic Acid | A collagen–HA-coated silk scaffold was transplanted into an Achilles tendon injury model. | Co-effect of silk and amniotic membrane for tendon repair. Seo YK, Kim JH, Eo SR. J Biomater Sci Polym Ed. 2016 Aug;27(12):1232-47. PMID: 27188627. |
| Hyaluronic Acid + EGF/bFGF | A scaffold was prepared then transplanted into a wound model system. | Effects of structurally stabilized EGF and bFGF on wound healing in type I and type II diabetic mice. Choi SM, Lee KM, Kim HJ, Park IK, Kang HJ, Shin HC, Baek D, Choi Y, Park KH, Lee JW. Acta Biomater. 2018 Jan 15;66:325-334. PMID: 29203426. |
| Polyurethane | A scaffold was prepared, and vascular smooth muscle cells were cultured. | Guiding the orientation of smooth muscle cells on random and aligned polyurethane/collagen nanofibers. Jia L, Prabhakaran MP, Qin X, Ramakrishna S. J Biomater Appl. 2014 Sep;29(3):364-77. PMID: 24682037. |
| β-Glycerophosphate + Chitosan + Quercetin | A scaffold was prepared, and periodontal ligament stem cells were cultured. | Characteristics and biologic effects of thermosensitive quercetin-chitosan/collagen hydrogel on human periodontal ligament stem cells. Arpornmaeklong P, Sareethammanuwat M, Apinyauppatham K, Boonyuen S. J Biomed Mater Res B Appl Biomater. 2021 Oct;109(10):1656-1670. PMID: 33644957. |
| PDMS: Polydimethylsiloxane | A scaffold was prepared, and hepatocytes and fibroblasts were co-cultured. | PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces. Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki. Sensors and Actuators B: Chemical. Volume 287, 2019, Pages 486-495. |
| PLCL: Poly (L-lactic acid)-co-poly(ε-caprolactone) + Polyaniline + Camphorsulfonic Acid | A scaffold was prepared, and adipose-derived mesenchymal stem cells were cultured. | The impact of electroconductive multifunctional composite nanofibrous scaffold on adipose-derived mesenchymal stem cells. Słysz A, Siennicka K, Kijeńska-Gawrońska E, Dębski T, Zołocińska A, Święszkowski W, Pojda Z. Tissue Cell. 2022 Oct;78:101899. PMID: 36030673. |
| PVP: Polyvinylpyrrolidone | A scaffold was prepared, and fibroblasts and mesenchymal stem cells were cultured. | Novel Use for Polyvinylpyrrolidone as a Macromolecular Crowder for Enhanced Extracellular Matrix Deposition and Cell Proliferation. Rashid R, Lim NS, Chee SM, Png SN, Wohland T, Raghunath M. Tissue Eng Part C Methods. 2014 Dec;20(12):994-1002. PMID: 24665935. |
These examples show just a few of the many ways Atelocollagen Powder has been applied in combination with other materials. we hope they provide you with inspiration for your next project!