EDN ELISA Kit

MBL Life Sciences

Catalog No.: MBL-7630

Product Description

The EDN ELISA Kit is based on sandwich ELISA and is capable of measuring Human EDN.
Upon activation, eosinophils secrete several cationic proteins including major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil-derived neurotoxin (EDN). EDN, also called eosinophil protein X (EPX), is a glycosylated single-chain protein with a molecular weight 18-21 kDa and is a member of the ribonuclease superfamily along with ECP11)-13). Although EDN has high sequence homology to ECP, EDN has 100-fold greater ribonuclease activity than ECP and neurotoxicity but not cytotoxicity9), 10). Eosinophil activation has been found to play an important role in inflammatory processes in allergic diseases. EDN can be a marker of eosinophil activation and degranulation. The “EDN ELISA Kit” is a useful reagent for specifically measuring Human EDN with high sensitivity by ELISA.

References

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