Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum)

Cosmo Bio

Catalog No.: CAC-TIP-TD-P07

BACKGROUND 

TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and 
tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral 
sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of 
human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) 
and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases. 
These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases 
and for evaluation of cellular or animal models of TDP-43 proteinopathy.

Product Specifications

• Application: ELISA, IHC, WB
• Reactivity: Rat, Human
• Clonality: Polyclonal
• Host: Rabbit

Citations for Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) – 1 Found

Kawahara, Yukio; Mieda-Sato, Ai. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2012;109(9):3347-52.