Anti ROCK2 pAb (ATL-HPA007459)

Atlas Antibodies

Catalog No.: ATL-HPA007459-25

Protein Description: Rho-associated, coiled-coil containing protein kinase 2
Gene Name: ROCK2
Alternative Gene Name:
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000020580: 91%, ENSRNOG00000004496: 89%
Entrez Gene ID: 9475
Uniprot ID: O75116
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: WB, IHC
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: FVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADK
• Gene Sequence: FVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADK
• Gene ID - Mouse: ENSMUSG00000020580
• Gene ID - Rat: ENSRNOG00000004496
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti ROCK2 pAb (ATL-HPA007459) – 7 Found

Mikami, Taro; Yoshida, Keiichiro; Sawada, Hajime; Esaki, Michiyo; Yasumura, Kazunori; Ono, Michio. Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells. Biological Research. 2015;48(1):48. 

Weiss, Jonathan M; Chen, Wei; Nyuydzefe, Melanie S; Trzeciak, Alissa; Flynn, Ryan; Tonra, James R; Marusic, Suzana; Blazar, Bruce R; Waksal, Samuel D; Zanin-Zhorov, Alexandra. ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings. Science Signaling. 2016;9(437):ra73. 

Zanin-Zhorov, Alexandra; Weiss, Jonathan M; Trzeciak, Alissa; Chen, Wei; Zhang, Jingya; Nyuydzefe, Melanie S; Arencibia, Carmen; Polimera, Seetharam; Schueller, Olivier; Fuentes-Duculan, Judilyn; Bonifacio, Kathleen M; Kunjravia, Norma; Cueto, Inna; Soung, Jennifer; Fleischmann, Roy M; Kivitz, Alan; Lebwohl, Mark; Nunez, Margarita; Woodson, Johnnie; Smith, Shondra L; West, Robert F; Berger, Mark; Krueger, James G; Ryan, John L; Waksal, Samuel D. Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10. Journal Of Immunology (Baltimore, Md. : 1950). 2017;198(10):3809-3814. 

Govaere, O; Petz, M; Wouters, J; Vandewynckel, Y-P; Scott, E J; Topal, B; Nevens, F; Verslype, C; Anstee, Q M; Van Vlierberghe, H; Mikulits, W; Roskams, T. The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma. Oncogene. 2017;36(47):6605-6616. 

Meng, Ya-Ming; Jiang, Xue; Zhao, Xinbao; Meng, Qiong; Wu, Sangqing; Chen, Yitian; Kong, Xiangzhan; Qiu, Xiaoyi; Su, Liangping; Huang, Cheng; Wang, Minghui; Liu, Chao; Wong, Ping-Pui. Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities. Nature Communications. 2021;12(1):6011. 

Bozóky, Benedek; Savchenko, Andrii; Csermely, Péter; Korcsmáros, Tamás; Dúl, Zoltán; Pontén, Fredrik; Székely, László; Klein, George. Novel signatures of cancer-associated fibroblasts. International Journal Of Cancer. 2013;133(2):286-93. 

Popkirov, Stoyan; Ayzenberg, Ilya; Hahn, Stefanie; Bauer, Jan; Denno, Yvonne; Rieckhoff, Nicole; Radzimski, Christiane; Hans, Volkmar H; Berg, Sebastian; Roghmann, Florian; Noldus, Joachim; Bien, Christian G; Skodda, Sabine; Wellmer, Jörg; Stöcker, Winfried; Krogias, Christos; Gold, Ralf; Schlegel, Uwe; Probst, Christian; Komorowski, Lars; Miske, Ramona; Kleiter, Ingo. Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis. Acta Neuropathologica Communications. 2017;5(1):40.