Recombinant Human Receptor Activator of Nuclear Factor-kB Ligand, His Tag (RANKL, His Tag)

ORF Biologics

Catalog No.: ORF.GF.RANKLH-10

Product Description

Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) is a key TNF superfamily cytokine essential for osteoclast differentiation, bone remodeling, and immune regulation. RANKL functions as a soluble or membrane-associated homotrimer that binds the RANK receptor to activate downstream pathways, including AKT-mediated survival signaling. Its activity is naturally modulated by the decoy receptor OPG. ORF Biologics’ recombinant RANKL with a C-terminal His tag is engineered for efficient affinity purification, improved handling, and straightforward detection in biochemical assays. This biologically active protein is produced to deliver high purity, structural integrity, and reliable batch-to-batch performance. It is ideal for studies involving osteoclastogenesis, bone biology, immune signaling, and TNF superfamily receptor–ligand interactions.

Product Application

• Osteoclast Differentiation Assays: Supports in-vitro induction, maturation, and functional analysis of osteoclasts from primary cells or cell lines
• RANK–RANKL Signaling Studies: Enables investigation of downstream pathways such as NF-KB, AKT, and MAPK in bone, immune, and cancer biology models
• Protein–Protein Interaction and Binding Assays: Ideal for studying interactions with RANK or OPG using ELISA, BLI/SPR, pull-down assays, or Ni-NTA–based immobilization
• Immune Cell Activation and Differentiation Models: Facilitates research on T cell activation, dendritic cell function, lymph node development, and broader TNF superfamily signaling

Format: Lyophilized

Product Specifications