Anti TOP1 mAb (Clone 6D8)

CUSABIO

Catalog No.:
CSB-RA792129A0HU-50
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Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.

Product Specifications
Application WB, IHC, IP, FC, ELISA
Reactivity Human
Clonality Monoclonal (Clone No.: 6D8)

Documents & Links for Anti TOP1 mAb (Clone 6D8)
Datasheet Anti TOP1 mAb (Clone 6D8) Datasheet

Documents & Links for Anti TOP1 mAb (Clone 6D8)
Datasheet Anti TOP1 mAb (Clone 6D8) Datasheet