Anti LAMTOR1 pAb (ATL-HPA002997)

Atlas Antibodies

Catalog No.: ATL-HPA002997-25

Protein Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Gene Name: LAMTOR1
Alternative Gene Name: C11orf59, FLJ20625, p18, p27RF-Rho, Pdro, Ragulator1
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000030842: 99%, ENSRNOG00000020016: 97%
Entrez Gene ID: 55004
Uniprot ID: Q6IAA8
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: NEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVV
• Gene Sequence: NEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVV
• Gene ID - Mouse: ENSMUSG00000030842
• Gene ID - Rat: ENSRNOG00000020016
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti LAMTOR1 pAb (ATL-HPA002997) – 7 Found

Filipek, Przemyslaw A; de Araujo, Mariana E G; Vogel, Georg F; De Smet, Cedric H; Eberharter, Daniela; Rebsamen, Manuele; Rudashevskaya, Elena L; Kremser, Leopold; Yordanov, Teodor; Tschaikner, Philipp; Fürnrohr, Barbara G; Lechner, Stefan; Dunzendorfer-Matt, Theresia; Scheffzek, Klaus; Bennett, Keiryn L; Superti-Furga, Giulio; Lindner, Herbert H; Stasyk, Taras; Huber, Lukas A. LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. The Journal Of Cell Biology. 2017;216(12):4199-4215. 

Stasyk, Taras; Holzmann, Johann; Stumberger, Sonja; Ebner, Hannes L; Hess, Michael W; Bonn, Guenther K; Mechtler, Karl; Huber, Lukas A. Proteomic analysis of endosomes from genetically modified p14/MP1 mouse embryonic fibroblasts. Proteomics. 2010;10(22):4117-27. 

Taub, Nicole; Nairz, Manfred; Hilber, Diana; Hess, Michael W; Weiss, Günter; Huber, Lukas A. The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. Journal Of Cell Science. 2012;125(Pt 11):2698-708. 

Martina, Jose A; Chen, Yong; Gucek, Marjan; Puertollano, Rosa. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy. 2012;8(6):903-14. 

Munson, Michael J; Allen, George Fg; Toth, Rachel; Campbell, David G; Lucocq, John M; Ganley, Ian G. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. The Embo Journal. 2015;34(17):2272-90. 

Sun, Jiandong; Liu, Yan; Jia, Yousheng; Hao, Xiaoning; Lin, Wei Ju; Tran, Jennifer; Lynch, Gary; Baudry, Michel; Bi, Xiaoning. UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity. Elife. 2018;7( 30020076) 

Singh, Jasjot; Elhabashy, Hadeer; Muthukottiappan, Pathma; Stepath, Markus; Eisenacher, Martin; Kohlbacher, Oliver; Gieselmann, Volkmar; Winter, Dominic. Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo. Nature Communications. 2022;13(1):6212.