Anti FUS pAb (ATL-HPA008784 w/enhanced validation)

Atlas Antibodies

SKU: ATL-HPA008784-25

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Protein Description: FUS RNA binding protein
Gene Name: FUS
Alternative Gene Name: ALS6, FUS1, hnRNP-P2, HNRNPP2, TLS
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000030795: 91%, ENSRNOG00000023360: 91%
Entrez Gene ID: 2521
Uniprot ID: P35637
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: WB, ICC, IHC
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDR
• Gene Sequence: SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDR
• Gene ID - Mouse: ENSMUSG00000030795
• Gene ID - Rat: ENSRNOG00000023360
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti FUS pAb (ATL-HPA008784 w/enhanced validation) – 38 Found

Ferrer, Isidre; Legati, Andrea; García-Monco, J Carlos; Gomez-Beldarrain, Marian; Carmona, Margarita; Blanco, Rosa; Seeley, William W; Coppola, Giovanni. Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy. Journal Of Neuropathology And Experimental Neurology. 2015;74(4):370-9. 

Barmada, Sami J; Ju, Shulin; Arjun, Arpana; Batarse, Anthony; Archbold, Hilary C; Peisach, Daniel; Li, Xingli; Zhang, Yuxi; Tank, Elizabeth M H; Qiu, Haiyan; Huang, Eric J; Ringe, Dagmar; Petsko, Gregory A; Finkbeiner, Steven. Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2015;112(25):7821-6. 

Kawakami, Ito; Kobayashi, Zen; Arai, Tetsuaki; Yokota, Osamu; Nonaka, Takashi; Aoki, Naoya; Niizato, Kazuhiro; Oshima, Kenichi; Higashi, Shinji; Katsuse, Omi; Hosokawa, Masato; Hasegawa, Masato; Akiyama, Haruhiko. Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration. Acta Neuropathologica Communications. 2016;4( 27044537):36. 

Mateju, Daniel; Franzmann, Titus M; Patel, Avinash; Kopach, Andrii; Boczek, Edgar E; Maharana, Shovamayee; Lee, Hyun O; Carra, Serena; Hyman, Anthony A; Alberti, Simon. An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function. The Embo Journal. 2017;36(12):1669-1687. 

Deshpande, Dhruva; Higelin, Julia; Schoen, Michael; Vomhof, Thomas; Boeckers, Tobias M; Demestre, Maria; Michaelis, Jens. Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses. Frontiers In Cellular Neuroscience. 13( 31244613):256. 

Lin, Yen-Chen; Kumar, Meenakshi Sundaram; Ramesh, Nandini; Anderson, Eric N; Nguyen, Aivi T; Kim, Boram; Cheung, Simon; McDonough, Justin A; Skarnes, William C; Lopez-Gonzalez, Rodrigo; Landers, John E; Fawzi, Nicolas L; Mackenzie, Ian R A; Lee, Edward B; Nickerson, Jeffrey A; Grunwald, David; Pandey, Udai B; Bosco, Daryl A. Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nature Neuroscience. 2021;24(8):1077-1088. 

Nicolas, Gaël; Sévigny, Myriam; Lecoquierre, François; Marguet, Florent; Deschênes, Andréanne; Del Pelaez, Maria Carment; Feuillette, Sébastien; Audebrand, Anaïs; Lecourtois, Magalie; Rousseau, Stéphane; Richard, Anne-Claire; Cassinari, Kévin; Deramecourt, Vincent; Duyckaerts, Charles; Boland, Anne; Deleuze, Jean-François; Meyer, Vincent; Clarimon Echavarria, Jordi; Gelpi, Ellen; Akiyama, Haruhiko; Hasegawa, Masato; Kawakami, Ito; Wong, Tsz H; Van Rooij, Jeroen G J; Van Swieten, John C; Campion, Dominique; Dutchak, Paul A; Wallon, David; Lavoie-Cardinal, Flavie; Laquerrière, Annie; Rovelet-Lecrux, Anne; Sephton, Chantelle F. A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics. Acta Neuropathologica Communications. 2022;10(1):20. 

Neumann, Manuela; Roeber, Sigrun; Kretzschmar, Hans A; Rademakers, Rosa; Baker, Matt; Mackenzie, Ian R A. Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease. Acta Neuropathologica. 2009;118(5):605-16. 

Neumann, Manuela; Rademakers, Rosa; Roeber, Sigrun; Baker, Matt; Kretzschmar, Hans A; Mackenzie, Ian R A. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain : A Journal Of Neurology. 2009;132(Pt 11):2922-31. 

Munoz, David G; Neumann, Manuela; Kusaka, Hirofumi; Yokota, Osamu; Ishihara, Kenji; Terada, Seishi; Kuroda, Shigetoshi; Mackenzie, Ian R. FUS pathology in basophilic inclusion body disease. Acta Neuropathologica. 2009;118(5):617-27. 

Seelaar, Harro; Klijnsma, Kirsten Y; de Koning, Inge; van der Lugt, Aad; Chiu, Wang Zheng; Azmani, Asma; Rozemuller, Annemieke J M; van Swieten, John C. Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration. Journal Of Neurology. 2010;257(5):747-53. 

Urwin, Hazel; Josephs, Keith A; Rohrer, Jonathan D; Mackenzie, Ian R; Neumann, Manuela; Authier, Astrid; Seelaar, Harro; Van Swieten, John C; Brown, Jeremy M; Johannsen, Peter; Nielsen, Jorgen E; Holm, Ida E; Dickson, Dennis W; Rademakers, Rosa; Graff-Radford, Neill R; Parisi, Joseph E; Petersen, Ronald C; Hatanpaa, Kimmo J; White, Charles L 3rd; Weiner, Myron F; Geser, Felix; Van Deerlin, Vivianna M; Trojanowski, John Q; Miller, Bruce L; Seeley, William W; van der Zee, Julie; Kumar-Singh, Samir; Engelborghs, Sebastiaan; De Deyn, Peter P; Van Broeckhoven, Christine; Bigio, Eileen H; Deng, Han-Xiang; Halliday, Glenda M; Kril, Jillian J; Munoz, David G; Mann, David M; Pickering-Brown, Stuart M; Doodeman, Valerie; Adamson, Gary; Ghazi-Noori, Shabnam; Fisher, Elizabeth M C; Holton, Janice L; Revesz, Tamas; Rossor, Martin N; Collinge, John; Mead, Simon; Isaacs, Adrian M. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta Neuropathologica. 2010;120(1):33-41. 

Deng, Han-Xiang; Zhai, Hong; Bigio, Eileen H; Yan, Jianhua; Fecto, Faisal; Ajroud, Kaouther; Mishra, Manjari; Ajroud-Driss, Senda; Heller, Scott; Sufit, Robert; Siddique, Nailah; Mugnaini, Enrico; Siddique, Teepu. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Annals Of Neurology. 2010;67(6):739-48. 

Kino, Yoshihiro; Washizu, Chika; Aquilanti, Elisa; Okuno, Misako; Kurosawa, Masaru; Yamada, Mizuki; Doi, Hiroshi; Nukina, Nobuyuki. Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations. Nucleic Acids Research. 2011;39(7):2781-98. 

Pikkarainen, Maria; Hartikainen, Päivi; Soininen, Hilkka; Alafuzoff, Irina. Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry. Cerebellum (London, England). 2011;10(4):720-31. 

Lashley, Tammaryn; Rohrer, Jonathan D; Bandopadhyay, Rina; Fry, Charles; Ahmed, Zeshan; Isaacs, Adrian M; Brelstaff, Jack H; Borroni, Barbara; Warren, Jason D; Troakes, Claire; King, Andrew; Al-Saraj, Safa; Newcombe, Jia; Quinn, Niall; Ostergaard, Karen; Schrøder, Henrik Daa; Bojsen-Møller, Marie; Braendgaard, Hans; Fox, Nick C; Rossor, Martin N; Lees, Andrew J; Holton, Janice L; Revesz, Tamas. A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies. Brain : A Journal Of Neurology. 2011;134(Pt 9):2548-64. 

Neumann, Manuela; Bentmann, Eva; Dormann, Dorothee; Jawaid, Ali; DeJesus-Hernandez, Mariely; Ansorge, Olaf; Roeber, Sigrun; Kretzschmar, Hans A; Munoz, David G; Kusaka, Hirofumi; Yokota, Osamu; Ang, Lee-Cyn; Bilbao, Juan; Rademakers, Rosa; Haass, Christian; Mackenzie, Ian R A. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain : A Journal Of Neurology. 2011;134(Pt 9):2595-609. 

Snowden, Julie S; Rollinson, Sara; Thompson, Jennifer C; Harris, Jennifer M; Stopford, Cheryl L; Richardson, Anna M T; Jones, Matthew; Gerhard, Alex; Davidson, Yvonne S; Robinson, Andrew; Gibbons, Linda; Hu, Quan; DuPlessis, Daniel; Neary, David; Mann, David M A; Pickering-Brown, Stuart M. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain : A Journal Of Neurology. 2012;135(Pt 3):693-708. 

Dormann, Dorothee; Madl, Tobias; Valori, Chiara F; Bentmann, Eva; Tahirovic, Sabina; Abou-Ajram, Claudia; Kremmer, Elisabeth; Ansorge, Olaf; Mackenzie, Ian R A; Neumann, Manuela; Haass, Christian. Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. The Embo Journal. 2012;31(22):4258-75. 

Dobson-Stone, Carol; Luty, Agnes A; Thompson, Elizabeth M; Blumbergs, Peter; Brooks, William S; Short, Cathy L; Field, Colin D; Panegyres, Peter K; Hecker, Jane; Solski, Jennifer A; Blair, Ian P; Fullerton, Janice M; Halliday, Glenda M; Schofield, Peter R; Kwok, John B J. Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis. Acta Neuropathologica. 2013;125(4):523-33. 

Qiu, Haiyan; Lee, Sebum; Shang, Yulei; Wang, Wen-Yuan; Au, Kin Fai; Kamiya, Sherry; Barmada, Sami J; Finkbeiner, Steven; Lui, Hansen; Carlton, Caitlin E; Tang, Amy A; Oldham, Michael C; Wang, Hejia; Shorter, James; Filiano, Anthony J; Roberson, Erik D; Tourtellotte, Warren G; Chen, Bin; Tsai, Li-Huei; Huang, Eric J. ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. The Journal Of Clinical Investigation. 2014;124(3):981-99. 

Nakamura, Masataka; Murray, Melissa E; Lin, Wen-Lang; Kusaka, Hirofumi; Dickson, Dennis W. Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease. American Journal Of Neurodegenerative Disease. 3(2):93-102. 

Sephton, Chantelle F; Tang, Amy A; Kulkarni, Ashwinikumar; West, James; Brooks, Mieu; Stubblefield, Jeremy J; Liu, Yun; Zhang, Michael Q; Green, Carla B; Huber, Kimberly M; Huang, Eric J; Herz, Joachim; Yu, Gang. Activity-dependent FUS dysregulation disrupts synaptic homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2014;111(44):E4769-78. 

Ayaki, Takashi; Ito, Hidefumi; Fukushima, Hiroko; Inoue, Takeshi; Kondo, Takayuki; Ikemoto, Akito; Asano, Takeshi; Shodai, Akemi; Fujita, Takuji; Fukui, Satoshi; Morino, Hiroyuki; Nakano, Satoshi; Kusaka, Hirofumi; Yamashita, Hirofumi; Ihara, Masafumi; Matsumoto, Riki; Kawamata, Jun; Urushitani, Makoto; Kawakami, Hideshi; Takahashi, Ryosuke. Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant. Acta Neuropathologica Communications. 2014;2( 25492614):172. 

Nakamura, Masataka; Bieniek, Kevin F; Lin, Wen-Lang; Graff-Radford, Neill R; Murray, Melissa E; Castanedes-Casey, Monica; Desaro, Pamela; Baker, Matthew C; Rutherford, Nicola J; Robertson, Janice; Rademakers, Rosa; Dickson, Dennis W; Boylan, Kevin B. A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration. Acta Neuropathologica. 2015;130(1):145-57. 

Ziskin, Jennifer L; Greicius, Michael D; Zhu, Wan; Okumu, Anna N; Adams, Christopher M; Plowey, Edward D. Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia. Acta Neuropathologica Communications. 2015;3( 26156087):43. 

Schoen, Michael; Reichel, Jochen M; Demestre, Maria; Putz, Stefan; Deshpande, Dhruva; Proepper, Christian; Liebau, Stefan; Schmeisser, Michael J; Ludolph, Albert C; Michaelis, Jens; Boeckers, Tobias M. Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons. Frontiers In Cellular Neuroscience. 9( 26834559):496. 

Scarioni, Marta; Gami-Patel, Priya; Timar, Yannick; Seelaar, Harro; van Swieten, John C; Rozemuller, Annemieke J M; Dols, Annemiek; Scarpini, Elio; Galimberti, Daniela; Hoozemans, Jeroen J M; Pijnenburg, Yolande A L; Dijkstra, Anke A. Frontotemporal Dementia: Correlations Between Psychiatric Symptoms and Pathology. Annals Of Neurology. 2020;87(6):950-961. 

Miki, Tomoko; Yokota, Osamu; Haraguchi, Takashi; Ishizu, Hideki; Hasegawa, Masato; Ishihara, Takeshi; Ueno, Shu-Ichi; Takenoshita, Shintaro; Terada, Seishi; Yamada, Norihito. Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases. Brain Pathology (Zurich, Switzerland). 2020;30(4):811-830. 

Nolan, Matthew; Scott, Connor; Gamarallage, Menuka Pallebage; Lunn, Daniel; Carpenter, Kilda; McDonough, Elizabeth; Meyer, Dan; Kaanumalle, Sireesha; Santamaria-Pang, Alberto; Turner, Martin R; Talbot, Kevin; Ansorge, Olaf. Quantitative patterns of motor cortex proteinopathy across ALS genotypes. Acta Neuropathologica Communications. 2020;8(1):98. 

Llibre-Guerra, Jorge J; Lee, Suzee E; Suemoto, Claudia K; Ehrenberg, Alexander J; Kovacs, Gabor G; Karydas, Anna; Staffaroni, Adam; Franca Resende, Elisa De Paula; Kim, Eun-Joo; Hwang, Ji-Hye; Ramos, Eliana Marisa; Wojta, Kevin J; Pasquini, Lorenzo; Pang, Shirley Yin-Yu; Spina, Salvatore; Allen, Isabel E; Kramer, Joel; Miller, Bruce L; Seeley, William W; Grinberg, Lea T. A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP. Brain Pathology (Zurich, Switzerland). 2021;31(2):267-282. 

Bayer, David; Antonucci, Stefano; Müller, Hans-Peter; Saad, Rami; Dupuis, Luc; Rasche, Volker; Böckers, Tobias M; Ludolph, Albert C; Kassubek, Jan; Roselli, Francesco. Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients. Translational Neurodegeneration. 2021;10(1):17. 

Bieniek, Kevin F; Josephs, Keith A; Lin, Wen-Lang; Dickson, Dennis W. Neuronal intermediate filament inclusion disease may be incorrectly classified as a subtype of FTLD-FUS. Free Neuropathology. 1( 34386806) 

Gleixner, Amanda M; Verdone, Brandie Morris; Otte, Charlton G; Anderson, Eric N; Ramesh, Nandini; Shapiro, Olivia R; Gale, Jenna R; Mauna, Jocelyn C; Mann, Jacob R; Copley, Katie E; Daley, Elizabeth L; Ortega, Juan A; Cicardi, Maria Elena; Kiskinis, Evangelos; Kofler, Julia; Pandey, Udai B; Trotti, Davide; Donnelly, Christopher J. NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nature Communications. 2022;13(1):3380. 

Shi, Minglei; You, Kaiqiang; Chen, Taoyu; Hou, Chao; Liang, Zhengyu; Liu, Mingwei; Wang, Jifeng; Wei, Taotao; Qin, Jun; Chen, Yang; Zhang, Michael Q; Li, Tingting. Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index. Genome Biology. 2021;22(1):229. 

Park, Hongsun; Yamanaka, Tomoyuki; Nukina, Nobuyuki. Proteomic analysis of heat-stable proteins revealed an increased proportion of proteins with compositionally biased regions. Scientific Reports. 2022;12(1):4347. 

Choi, Byung Jo; Park, Kang Ho; Park, Min Hee; Huang, Eric Jinsheng; Kim, Seung Hyun; Bae, Jae-Sung; Jin, Hee Kyung. Acid sphingomyelinase inhibition improves motor behavioral deficits and neuronal loss in an amyotrophic lateral sclerosis mouse model. Bmb Reports. 2022;55(12):621-626. 

Scarioni, Marta; Gami-Patel, Priya; Peeters, Carel F W; de Koning, Florianne; Seelaar, Harro; Mol, Merel O; van Swieten, John C; Rozemuller, Annemieke J M; Hoozemans, Jeroen J M; Pijnenburg, Yolande A L; Dijkstra, Anke A. Psychiatric symptoms of frontotemporal dementia and subcortical (co-)pathology burden: new insights. Brain : A Journal Of Neurology. 2023;146(1):307-320.