Anti Chondroitin Sulfate A mAb (Clone 2H6)

Cosmo Bio LTD

Catalog No: CAC-NU-07-001

Catalog numbers beginning with "CAC" are antibodies from our exclusive Cosmo Bio Antibody Collection. Visit the CAC Antibody homepage to browse the collection list, organized by research topic.

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Application: IP, IHC(p), WB, IHC(f), ELISA 
Clonality: Monoclonal 
Host: Mouse 
Purification: Ion-exchange Chromatography 
Reactivity: All 

Chondroitin sulfate, a polysaccharide moiety of proteoglycans, is one of the major components of the extracellular matrix. It is composed of the repeating unit, [→4GlcA 1→3GalNAc 1→], commonly sulfated at C-4 and/or C-6 of GalNAc. In the central nervous system, the most abundant glycosaminoglycan is chondroitin sulfate rich in [GlcA-GalNAc(4S)], namely chondroitin sulfate A. Chondroitin sulfate polysaccharides are involved in the formation, regeneration, and maintenance of the neural network. This monoclonal antibody effectively recognizes chondroitin sulfate A, especially in glycosaminoglycans occurring in the developing central nervous system.

References:
1) Oohira, A., et al. (1994) Neuroscience. 60:145-157. PMID: 8052408.
2) Yamamoto, Y., et al. (1995) Eur. J. Histochem. 39:265-272. PMID: 8835180.

Citations for Anti Chondroitin Sulfate A mAb (Clone 2H6) – 1 Found

Kamermans et al. 2019. Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production. Glia. 67(1):68-77.   , Journal