Anti C9orf72 pAb (ATL-HPA023873)

Atlas Antibodies

SKU: ATL-HPA023873-25

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Protein Description: chromosome 9 open reading frame 72
Gene Name: C9orf72
Alternative Gene Name: MGC23980
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000028300: 97%, ENSRNOG00000009478: 94%
Entrez Gene ID: 203228
Uniprot ID: Q96LT7
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: YGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSVPEEI
• Gene Sequence: YGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSVPEEI
• Gene ID - Mouse: ENSMUSG00000028300
• Gene ID - Rat: ENSRNOG00000009478
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti C9orf72 pAb (ATL-HPA023873) – 7 Found

Busch, Johanna I; Unger, Travis L; Jain, Nimansha; Tyler Skrinak, R; Charan, Rakshita A; Chen-Plotkin, Alice S. Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes. Human Molecular Genetics. 2016;25(13):2681-2697. 

Shi, Yingxiao; Lin, Shaoyu; Staats, Kim A; Li, Yichen; Chang, Wen-Hsuan; Hung, Shu-Ting; Hendricks, Eric; Linares, Gabriel R; Wang, Yaoming; Son, Esther Y; Wen, Xinmei; Kisler, Kassandra; Wilkinson, Brent; Menendez, Louise; Sugawara, Tohru; Woolwine, Phillip; Huang, Mickey; Cowan, Michael J; Ge, Brandon; Koutsodendris, Nicole; Sandor, Kaitlin P; Komberg, Jacob; Vangoor, Vamshidhar R; Senthilkumar, Ketharini; Hennes, Valerie; Seah, Carina; Nelson, Amy R; Cheng, Tze-Yuan; Lee, Shih-Jong J; August, Paul R; Chen, Jason A; Wisniewski, Nicholas; Hanson-Smith, Victor; Belgard, T Grant; Zhang, Alice; Coba, Marcelo; Grunseich, Chris; Ward, Michael E; van den Berg, Leonard H; Pasterkamp, R Jeroen; Trotti, Davide; Zlokovic, Berislav V; Ichida, Justin K. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature Medicine. 2018;24(3):313-325. 

Snowden, Julie S; Rollinson, Sara; Thompson, Jennifer C; Harris, Jennifer M; Stopford, Cheryl L; Richardson, Anna M T; Jones, Matthew; Gerhard, Alex; Davidson, Yvonne S; Robinson, Andrew; Gibbons, Linda; Hu, Quan; DuPlessis, Daniel; Neary, David; Mann, David M A; Pickering-Brown, Stuart M. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain : A Journal Of Neurology. 2012;135(Pt 3):693-708. 

Brettschneider, Johannes; Van Deerlin, Vivianna M; Robinson, John L; Kwong, Linda; Lee, Edward B; Ali, Yousuf O; Safren, Nathaniel; Monteiro, Mervyn J; Toledo, Jon B; Elman, Lauren; McCluskey, Leo; Irwin, David J; Grossman, Murray; Molina-Porcel, Laura; Lee, Virginia M-Y; Trojanowski, John Q. Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion. Acta Neuropathologica. 2012;123(6):825-39. 

Satoh, Jun-Ichi; Tabunoki, Hiroko; Ishida, Tsuyoshi; Saito, Yuko; Arima, Kunimasa. Dystrophic neurites express C9orf72 in Alzheimer's disease brains. Alzheimer's Research & Therapy. 2012;4(4):33. 

Wen, Xinmei; Tan, Wenzhi; Westergard, Thomas; Krishnamurthy, Karthik; Markandaiah, Shashirekha S; Shi, Yingxiao; Lin, Shaoyu; Shneider, Neil A; Monaghan, John; Pandey, Udai B; Pasinelli, Piera; Ichida, Justin K; Trotti, Davide. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron. 2014;84(6):1213-25. 

Abo-Rady, Masin; Kalmbach, Norman; Pal, Arun; Schludi, Carina; Janosch, Antje; Richter, Tanja; Freitag, Petra; Bickle, Marc; Kahlert, Anne-Karin; Petri, Susanne; Stefanov, Stefan; Glass, Hannes; Staege, Selma; Just, Walter; Bhatnagar, Rajat; Edbauer, Dieter; Hermann, Andreas; Wegner, Florian; Sterneckert, Jared L. Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins. Stem Cell Reports. 2020;14(3):390-405.