Anti ADPRHL2 pAb (ATL-HPA027104 w/enhanced validation)

Atlas Antibodies

SKU:
ATL-HPA027104-25
  • Immunohistochemical staining of human Fallopian tube shows strong cytoplasmic and nuclear positivity in glandular cells.
  • Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
  • Western blot analysis in U-87MG ATCC cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-ADPRHL2 antibody. Remaining relative intensity is presented. Loading control: Anti-PPIB.
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Protein Description: ADP-ribosylhydrolase like 2
Gene Name: ADPRHL2
Alternative Gene Name: ARH3, FLJ20446
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000042558: 91%, ENSRNOG00000010849: 91%
Entrez Gene ID: 54936
Uniprot ID: Q9NX46
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications
Application WB, ICC, IHC
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Host Rabbit
Immunogen SEHFLKQLLGHMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLR
Gene Sequence SEHFLKQLLGHMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLR
Gene ID - Mouse ENSMUSG00000042558
Gene ID - Rat ENSRNOG00000010849
Buffer 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.



Documents & Links for Anti ADPRHL2 pAb (ATL-HPA027104 w/enhanced validation)
Datasheet Anti ADPRHL2 pAb (ATL-HPA027104 w/enhanced validation) Datasheet (External Link)
Vendor Page Anti ADPRHL2 pAb (ATL-HPA027104 w/enhanced validation)



Citations for Anti ADPRHL2 pAb (ATL-HPA027104 w/enhanced validation) – 5 Found
Fontana, Pietro; Bonfiglio, Juan José; Palazzo, Luca; Bartlett, Edward; Matic, Ivan; Ahel, Ivan. Serine ADP-ribosylation reversal by the hydrolase ARH3. Elife. 2017;6( 28650317)  PubMed
Palazzo, Luca; Leidecker, Orsolya; Prokhorova, Evgeniia; Dauben, Helen; Matic, Ivan; Ahel, Ivan. Serine is the major residue for ADP-ribosylation upon DNA damage. Elife. 2018;7( 29480802)  PubMed
Bartlett, Edward; Bonfiglio, Juan José; Prokhorova, Evgeniia; Colby, Thomas; Zobel, Florian; Ahel, Ivan; Matic, Ivan. Interplay of Histone Marks with Serine ADP-Ribosylation. Cell Reports. 2018;24(13):3488-3502.e5.  PubMed
Hanzlikova, Hana; Prokhorova, Evgeniia; Krejcikova, Katerina; Cihlarova, Zuzana; Kalasova, Ilona; Kubovciak, Jan; Sachova, Jana; Hailstone, Richard; Brazina, Jan; Ghosh, Shereen; Cirak, Sebahattin; Gleeson, Joseph G; Ahel, Ivan; Caldecott, Keith W. Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair. Nature Communications. 2020;11(1):3391.  PubMed
Prokhorova, Evgeniia; Zobel, Florian; Smith, Rebecca; Zentout, Siham; Gibbs-Seymour, Ian; Schützenhofer, Kira; Peters, Alessandra; Groslambert, Joséphine; Zorzini, Valentina; Agnew, Thomas; Brognard, John; Nielsen, Michael L; Ahel, Dragana; Huet, Sébastien; Suskiewicz, Marcin J; Ahel, Ivan. Serine-linked PARP1 auto-modification controls PARP inhibitor response. Nature Communications. 2021;12(1):4055.  PubMed