Anti STX17 pAb (ATL-HPA001204 w/enhanced validation)

Atlas Antibodies

Catalog No.: ATL-HPA001204-25

Protein Description: syntaxin 17
Gene Name: STX17
Alternative Gene Name: FLJ20651
Isotype: IgG
Interspecies mouse/rat: ENSMUSG00000061455: 90%, ENSRNOG00000005801: 86%
Entrez Gene ID: 55014
Uniprot ID: P56962
Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage Temperature: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Product Specifications

• Application: WB, IHC
• Reactivity: Human
• Clonality: Polyclonal
• Host: Rabbit
• Immunogen: RLEPAIQKFIKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNIREIEKLCLKVRKDDLVLLKRMIDPVKEEASAATAEFLQLHLESVEELKKQFNDEETLLQPPLTRSMTVGGAFHTTEAEASSQSLTQ
• Gene Sequence: RLEPAIQKFIKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNIREIEKLCLKVRKDDLVLLKRMIDPVKEEASAATAEFLQLHLESVEELKKQFNDEETLLQPPLTRSMTVGGAFHTTEAEASSQSLTQ
• Gene ID - Mouse: ENSMUSG00000061455
• Gene ID - Rat: ENSRNOG00000005801
• Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

Citations for Anti STX17 pAb (ATL-HPA001204 w/enhanced validation) – 48 Found

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Kimura, Tomonori; Jia, Jingyue; Kumar, Suresh; Choi, Seong Won; Gu, Yuexi; Mudd, Michal; Dupont, Nicolas; Jiang, Shanya; Peters, Ryan; Farzam, Farzin; Jain, Ashish; Lidke, Keith A; Adams, Christopher M; Johansen, Terje; Deretic, Vojo. Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy. The Embo Journal. 2017;36(1):42-60. 

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Uematsu, Masaaki; Nishimura, Taki; Sakamaki, Yuriko; Yamamoto, Hayashi; Mizushima, Noboru. Accumulation of undegraded autophagosomes by expression of dominant-negative STX17 (syntaxin 17) mutants. Autophagy. 2017;13(8):1452-1464. 

Jung, Jennifer; Behrends, Christian. Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures. Bio-Protocol. 2017;7(17):27982478. 

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Kimura, Hana; Arasaki, Kohei; Ohsaki, Yuki; Fujimoto, Toyoshi; Ohtomo, Takayuki; Yamada, Junji; Tagaya, Mitsuo. Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3. Journal Of Lipid Research. 2018;59(5):805-819. 

Hua, Rongrong; Han, Song; Zhang, Nan; Dai, Qingqing; Liu, Ting; Li, Junfa. cPKCγ-Modulated Sequential Reactivation of mTOR Inhibited Autophagic Flux in Neurons Exposed to Oxygen Glucose Deprivation/Reperfusion. International Journal Of Molecular Sciences. 2018;19(5) 

Matsui, Takahide; Jiang, Peidu; Nakano, Saori; Sakamaki, Yuriko; Yamamoto, Hayashi; Mizushima, Noboru. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. The Journal Of Cell Biology. 2018;217(8):2633-2645. 

Wang, Chenyao; Wang, Huafei; Zhang, Deyi; Luo, Wenwen; Liu, Ruilong; Xu, Daqian; Diao, Lei; Liao, Lujian; Liu, Zhixue. Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy. Nature Communications. 2018;9(1):3492. 

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Yang, Huan; Shen, Hongtao; Li, Jing; Guo, Lian-Wang. SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance. Autophagy. 2019;15(9):1539-1557. 

Xian, Hongxu; Yang, Qiaoyun; Xiao, Lin; Shen, Han-Ming; Liou, Yih-Cherng. STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism. Nature Communications. 2019;10(1):2059. 

Shen, Qiuhong; Shi, Yin; Liu, Jiaqi; Su, Hua; Huang, Jingtao; Zhang, Yi; Peng, Chao; Zhou, Tianhua; Sun, Qiming; Wan, Wei; Liu, Wei. Acetylation of STX17 (syntaxin 17) controls autophagosome maturation. Autophagy. 2021;17(5):1157-1169. 

Li, Ruolin; Lu, Yongquan; Zhang, Qidi; Liu, Weijin; Yang, Runing; Jiao, Jie; Liu, Jia; Gao, Ge; Yang, Hui. Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model. Autophagy. 2022;18(3):559-575. 

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Li, Ting; Lu, Dingyi; Yao, Chengcheng; Li, Tingting; Dong, Hua; Li, Zhan; Xu, Guang; Chen, Jiayi; Zhang, Hao; Yi, Xiaoyu; Zhu, Haizhen; Liu, Guangqin; Wen, Kaiqing; Zhao, Haixin; Gao, Jun; Zhang, Yakun; Han, Qiuying; Li, Teng; Zhang, Weina; Zhao, Jie; Li, Tao; Bai, Zhaofang; Song, Moshi; He, Xinhua; Zhou, Tao; Xia, Qing; Li, Ailing; Pan, Xin. Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. Nature Communications. 2022;13(1):931. 

Jiang, Peidu; Nishimura, Taki; Sakamaki, Yuriko; Itakura, Eisuke; Hatta, Tomohisa; Natsume, Tohru; Mizushima, Noboru. The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Molecular Biology Of The Cell. 2014;25(8):1327-37. 

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Ren, Huimei; Elgner, Fabian; Jiang, Bingfu; Himmelsbach, Kiyoshi; Medvedev, Regina; Ploen, Daniela; Hildt, Eberhard. The Autophagosomal SNARE Protein Syntaxin 17 Is an Essential Factor for the Hepatitis C Virus Life Cycle. Journal Of Virology. 2016;90(13):5989-6000. 

McLelland, Gian-Luca; Lee, Sydney A; McBride, Heidi M; Fon, Edward A. Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system. The Journal Of Cell Biology. 2016;214(3):275-91. 

Beckerman, Pazit; Bi-Karchin, Jing; Park, Ae Seo Deok; Qiu, Chengxiang; Dummer, Patrick D; Soomro, Irfana; Boustany-Kari, Carine M; Pullen, Steven S; Miner, Jeffrey H; Hu, Chien-An A; Rohacs, Tibor; Inoue, Kazunori; Ishibe, Shuta; Saleem, Moin A; Palmer, Matthew B; Cuervo, Ana Maria; Kopp, Jeffrey B; Susztak, Katalin. Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nature Medicine. 2017;23(4):429-438. 

Fu, Ruoqiu; Deng, Qin; Zhang, Hongwei; Hu, Xiaoye; Li, Yunong; Liu, Yanxia; Hu, Jinjiao; Luo, Qingsong; Zhang, Yanhao; Jiang, Xiuxing; Li, Lirong; Yang, Chong; Gao, Ning. A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3. Cell Death & Disease. 2018;9(2):243. 

Barbero-Camps, Elisabet; Roca-Agujetas, Vicente; Bartolessis, Isabel; de Dios, Cristina; Fernández-Checa, Jose C; Marí, Montserrat; Morales, Albert; Hartmann, Tobias; Colell, Anna. Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion. Autophagy. 14(7):1129-1154. 

Wu, Man; Lao, Yuan-Zhi; Tan, Hong-Sheng; Lu, Guang; Ren, Yi; Zheng, Zhao-Qing; Yi, Juan; Fu, Wen-Wei; Shen, Han-Ming; Xu, Hong-Xi. Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation. Acta Pharmacologica Sinica. 2019;40(7):929-937. 

Xia, Yu; Liu, Na; Xie, Xiuxiu; Bi, Guoyu; Ba, Hongping; Li, Lin; Zhang, Jinxia; Deng, Xiaofei; Yao, Yao; Tang, Zhaohui; Yin, Binjiao; Wang, Jing; Jiang, Kan; Li, Zhuoya; Choi, Yongwon; Gong, Feili; Cheng, Xiang; O'Shea, John J; Chae, Jae Jin; Laurence, Arian; Yang, Xiang-Ping. The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion. Autophagy. 2019;15(6):960-975. 

Kumar, Suresh; Gu, Yuexi; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Jain, Ashish; Farzam, Farzin; Mudd, Michal; Anonsen, Jan Haug; Rusten, Tor Erik; Kasof, Gary; Ktistakis, Nicholas; Lidke, Keith A; Johansen, Terje; Deretic, Vojo. Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation. Developmental Cell. 2019;49(1):130-144.e6. 

Turco, Eleonora; Witt, Marie; Abert, Christine; Bock-Bierbaum, Tobias; Su, Ming-Yuan; Trapannone, Riccardo; Sztacho, Martin; Danieli, Alberto; Shi, Xiaoshan; Zaffagnini, Gabriele; Gamper, Annamaria; Schuschnig, Martina; Fracchiolla, Dorotea; Bernklau, Daniel; Romanov, Julia; Hartl, Markus; Hurley, James H; Daumke, Oliver; Martens, Sascha. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Molecular Cell. 2019;74(2):330-346.e11. 

Vats, Somya; Manjithaya, Ravi. A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes. Molecular Biology Of The Cell. 2019;30(17):2283-2295. 

Tian, Xiaoyu; Zheng, Pengli; Zhou, Chenqian; Wang, Xurui; Ma, Hua; Ma, Wei; Zhou, Xiaokai; Teng, Junlin; Chen, Jianguo. DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B. Autophagy. 2020;16(5):797-810. 

Gao, Guang; Zhu, Chengjia; Liu, Emma; Nabi, Ivan R. Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules. Plos Biology. 2019;17(8):e3000355. 

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